PUBLIC TRANSPORT AND INNOVATION
The effective functioning of the transport system of the region creates the necessary conditions for the development of the economy and the social sphere.
Nina Demidovna Berman +1 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Benchmarking public transport accessibility in Australasian cities [PDF]
There is growing recognition by all tiers of government that transformation of the public transport system is necessary if it is to offer a real alternative to car-based travel in Australasian cities.
Curtis, Carey, Scheurer, Jan
core
Regional public transport integration in Lithuania
Regional public transport organization helps to avoid additional route coordination, public transport service should not be limited to the boundaries of municipalities, which is currently regulated by the Law on Local Self-Government of the Republic of ...
Andrius Samuilovas +1 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Transport outlook 2009: Globalisation, crisis and transport [PDF]
This second ITF Transport Outlook continues building towards a full-fledged Transport Outlook, building upon the first Outlook (JTRC, 20081). The 2008 Outlook investigated the relation between expected GDP evolution and the demand for road transport ...
International Transport Forum, OECD
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The personal safety burden for women taking public transport in Australia and implications for provision of equitable public transport [PDF]
Travel on public transport for women is associated with concerns about safety from harassment and violence, and women may avoid public transport or make changes to their travel as a consequence.
Byron W. Keating +8 more
core +1 more source

