Results 91 to 100 of about 16,573,649 (256)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Social Media Reporting: How to Do It Right for Strategic Decision Making

Journalism and Media
As social media became essential for communication, organizations collected vast data from platforms like Facebook, Twitter (X), Instagram, and LinkedIn.
Anantasha Titisania Rimadewi, Yudi Azis, Diana Sari, Imas Soemaryani   +3 more
doaj   +1 more source

Interactive Political Leadership in Theory and Practice: How Elected Politicians May Benefit from Co-Creating Public Value Outcomes

Administrative Sciences, 2019
This paper argues that elected politicians may strengthen their political leadership role by initiating, orchestrating and engaging in the co-creation of public value outcomes.
Jacob Torfing, Eva Sørensen
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

From SDG alignment to SDG-ready public administration: institutional capacity, collaborative governance, and trust in Portuguese sustainability governance

Frontiers in Political Science
The 2030 Agenda has transformed sustainability from a planning and reporting agenda into a demanding public-administration challenge. Governments are expected not only to align policies with the Sustainable Development Goals (SDGs), but also to ...
Maria Asensio, Maria Asensio, Alexandra Ribeiro, Ricardo Dias   +3 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Publieke waarde van kunst en cultuur

Locus
De Raad voor Cultuur heeft onlangs het rapport Maken (z)onder druk uitgebracht over artistieke vrijheid als democratisch fundament. Volgens de Raad is er de afgelopen jaren sprake van een toename van de maatschappelijke druk op de vrijheid van ...
Peter van der Zant
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Operationalizing public value and the travel experience with artificial intelligence: a longitudinal analysis of user sentiment at subway stations in São Paulo and Porto

Frontiers in Future Transportation
IntroductionUrban mobility has emerged as a key factor in the challenge of achieving social and environmental sustainability in major Latin American metropolises such as São Paulo (Brazil), whose metro system has a high passenger density and an ...
Hadassa Souza, Álvaro Costa, Rodrigo Ribeiro de Oliveira   +2 more
doaj   +1 more source

MEASURING PUBLIC SECTOR INNOVATION: FROM INTERNATIONAL THEORETICAL FRAMEWORKS TO AN ADAPTATION STRATEGY FOR VIETNAM [PDF]

European Vector of Economic Development
This study presents a comprehensive framework for measuring public sector innovation (PSI) in Vietnam, integrating international theoretical models with evidence from the country’s unique governance context.
Phan Minh Duc, Duong Ngoc Anh
doaj   +1 more source