Results 81 to 90 of about 16,573,649 (256)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Managing Algorithms for Public Value [PDF]
, 2021 Public organisations increasingly rely on machine learning algorithms in performing many of their core activities. It is therefore important to consider how algorithms are transforming the public sector.
Selten, Friso, Meijer, Albert
core
Editorial: Public value for all? Considering the parameters of public value co-creation
, 2023 The aim behind this Public Money & Management theme is to explore the parameters of public value co-creation in order to open up a broader discussion of dis/value, public value destruction and co-destruction as a developing theme in the literature ...
Cluley, Victoria +2 more
core +1 more source
Rethinking Public Organizations as Knowledge-Oriented and Technology-Driven Organizations
Management Dynamics in the Knowledge Economy, 2017 Public organizations should rediscover the role of knowledge as a source for designing and implementing internal processes and adopt a knowledge management approach by using and managing technology as means and enabler for building a citizen-centered ...
Mauro ROMANELLI
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Public value, politics and public management: a literature review
, 2006 This paper summarises the findings of the literature review on politics and public management and sets out the theoretical background that underpins the concept of Public Value.
Lekhi, R., Horner, L., Blaug, R.
core
3D Geo-Information Innovation in Europe’s Public Mapping Agencies: A Public Value Perspective
Land, 2018 Intensifying and increasingly complex physical developments under, on, and above ground, as well as the speed and accessibility of digital innovation, is resulting in growing interest in public sector investment in 3D geo-information.
Serene Ho +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
“Imagining What We Know”: The Humanities in a Utilitarian Age
Humanities, 2014 This paper explores the ways that critics writing in the early nineteenth century developed arguments in favor of what we think of today as the humanities in the face of utilitarian pressures that dismissed the arts as self-indulgent pursuits incapable ...
Paul Keen
doaj +1 more source