Results 101 to 110 of about 16,573,649 (256)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Co-creating public value into digital-based public service innovation in the village governance

Otoritas: Jurnal Ilmu Pemerintahan
Digital technology is a solution in improving public services and governance, such as in administrative services with open access information. In organizing public services, the Hamparan Perak village government uses web-based applications, which aim to ...
Siti Hajar, Nur Ambia Arma
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Quantifying Public Value Creation by Public Service Media Using Big Programming Data

International Journal of Communication, 2023
In recent years, a renewed interest in how public service media (PSM) generate public value has emerged emphasizing how such value may express itself in multidimensional and nonlinear ways.
Indrek Ibrus, Andres Karjus, Vejune Zemaityte, Ulrike Rohn, Maximilian Schich   +4 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sustaining Participation for Rediscovering the Citizenship: Technology for public value

, 2018
Technologies open up to public organization sustaining democracy, restoring public trust, promoting public interest as responsive institutions fostering citizenship and collaboration in order to uphold participation in front of citizens feeling unheard ...
Mauro Romanelli
core  

Coping with public value conflicts

, 2016
Good governance involves managing conflicting values, leading to the main research question, which consists of three parts: Which public value profiles do public administrators have, which value conflicts do they experience, and which coping strategies ...
Gjalt de Graaf, Huberts, L.W.J.C., de Graaf, G., de Graaf, G.; id_orcid, Smulders, R., Remco Smulders, Leo Huberts, Huberts, L.W.J.C.; id_orcid   +7 more
core   +1 more source

The Clinical, Humanistic, and Economic Burden of Idiopathic Hypersomnia in the United States: Analysis of the National Health and Wellness Survey

Nature and Science of Sleep
Caroleen Drachenberg,1 M Janelle Cambron-Mellott,2 Lin Yang,2 Bridget L Balkaran,2 Marisa Whalen,3 David T Plante4 1Global Value & HEOR, Jazz Pharmaceuticals, Palo Alto, CA, USA; 2Oracle Life Sciences, Oracle Corporation, Austin, TX, USA; 3US Medical
Drachenberg C, Cambron-Mellott MJ, Yang L, Balkaran BL, Whalen M, Plante DT   +5 more
doaj  

The governance imperative: The influence of effective governance in unlocking intrapreneurial potential for sustainable public value

Africa’s Public Service Delivery & Performance Review
Background: Environmental, Social, and Governance (ESG) practices are gaining traction, with a particular focus on State-Owned Enterprises (SOEs) and their contribution to sustainability.
Lucy T. Chamba, Ismael Tarirai
doaj   +1 more source