Results 131 to 140 of about 11,862,425 (370)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Evaluation of oral health among people with multimorbidity in the marginalized population of Karachi, Pakistan: A multicenter cross-sectional study

open access: yesJournal of Taibah University Medical Sciences
الملخص: أهداف البحث: ترتبط صحة الفم بالصحة الجسدية والعقلية. تعد أمراض الفم شائعة بين الفقراء والمحرومين اجتماعيا واقتصاديا في البلدان النامية والصناعية.
Hina Sharif, Pharm-D, MSPH   +5 more
doaj   +1 more source

Managing for change: July 9, 1990 v. 1, no. 2 [PDF]

open access: yes, 1990
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Boston University Medical Center, Office of Publication Services
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Special connections: June 4, 1990 [PDF]

open access: yes, 1990
Time-sensitive news update to monthly University Hospital ...
Office of Publication Services, Boston University Medical Center
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Special connections: October 14, 1992 [PDF]

open access: yes, 1992
Time-sensitive news update to monthly University Hospital ...
Office of Publication Services, Boston University Medical Center
core  

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