Results 41 to 50 of about 3,170,256 (246)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

PlumX As a Potential Tool to Assess the Macroscopic Multidimensional Impact of Books

open access: yesFrontiers in Research Metrics and Analytics, 2017
The main purpose of this macro-study is to shed light on the broad impact of books. For this purpose, the impact of a very large collection of books (more than 200,000) has been analyzed by using PlumX, an analytical tool providing a great number of ...
Daniel Torres-Salinas   +3 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Investigating SSH Research and Publication Practices in Disciplinary and Institutional Contexts. A Survey-Based Comparative Approach in Two Universities

open access: yesFrontiers in Research Metrics and Analytics, 2019
In this paper, we comparatively analyze, present and discuss the results from a survey on increasing the visibility of research achievements in the social sciences and humanities (SSH) that was carried out at the University of Vienna (Austria) and the ...
Florian Bayer   +5 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

Laparoscopic resection of retroperitoneal paraganglioma close to caudal vena cava in a dog

open access: yesVeterinary Medicine and Science, 2021
Objective To report laparoscopic resection of retroperitoneal paraganglioma close to the caudal vena cava in a dog. Study design Case report. Animal Twelve‐year‐old, neutered male Jack Russell terrier.
Young Tae Park, Tomomi Minamoto
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Protein kinase FAM20C—when subcellular localization matters

open access: yesFEBS Letters, EarlyView.
FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley   +1 more source

Research Trends and Patterns on Emotional Intelligence in Education: A Bibliometric and Knowledge Mapping During 2012–2021

open access: yesOpen Education Studies
The increasing rate of publications on emotional intelligence, especially regarding student learning, underscores the need to study research trends in this domain.
Solih Mohamed   +4 more
doaj   +1 more source

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