Results 121 to 130 of about 10,759,414 (300)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Publication

open access: yes, 2014
<p>Release for publication of the accompanying paper.</p ...
Konrad Rudolph
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Increasing Time for Preparing a Candidate’s Dissertation and ‘Ageing’ of Young Scientists

open access: yesВысшее образование в России
Many researchers note the existence of systemic problems in the training of highly qualified scientific personnel, in particular candidates of science.
S. I. Pakhomov   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Let’s get physical : exploring the perceptions of physical activity participation and counselling among Australian medical students

open access: yes, 2017
Physicians have been identified as important promoters of physical activity (PA) – a modifiable risk factor for a range of chronic diseases. Evidence suggests, however, that physicians may not always be equipped to provide PA counselling due to a lack of
George, Emma S. (R17418)   +2 more
core  

“An Assistant in Your Pocket”: How Generative AI Shapes the Publishing Practices of Russian Postgraduate Students

open access: yesВысшее образование в России
Generative artificial intelligence (GenAI) is a serious challenge for science and education. To investigate the key dimensions of its perception, we conducted an applied sociological study involving Russian postgraduate students.
E. A. Koval   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

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