Results 51 to 60 of about 9,872,863 (284)

The Filter Bubble: What the Internet Is Hiding from You

, 2012
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Julie Allen
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Soviet heritage: community clubs, palaces of culture and other cultural buildings of Kamensk-Uralsky erected in the 1940s

Архитектон
The article provides a historical and architectural analysis of the unique heritage of the Soviet era – the community clubs and palaces of culture in Kamensk-Uralsky erected in the 1940s.
Gavrilova Svetlana I.
doaj   +1 more source

Emergent Information, a Unified Theory of Information Framework Vol. 3. By Wolfgang Hofkirchner, World Scientific, 2013; 280 Pages. Price £ 58.00, ISBN 978-981-4313-48-3

Information, 2013
The following paragraphs are reproduced from the website of the publisher [1]. At the dawn of the information age, a proper understanding of information and how it relates to matter and energy is of utmost importance for the survival of civilisation. Yet,
Shu-Kun Lin
doaj   +1 more source

Handbook of Applied Cryptography

, 2018
From the Publisher: A valuable reference for the novice as well as for the expert who needs a wider scope of coverage within the area of cryptography, this book provides easy and rapid access of information and includes more than 200 algorithms and ...
A. Menezes, P. V. Oorschot, S. Vanstone
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Historical architectural analysis of the youth complex of the Ural Aluminum Plant in Kamensk-Uralsky

Архитектон
The article provides a comparative historical architectural analysis of several versions of the design from the 1950s - early 1960s for an architectural and landscape ensemble consisting of the Palace of Pioneers, the Salut Sports Complex, and the ...
Gavrilova Svetlana I.
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Science Communication in Electronic Journals in the Field of Traffic and Transport

Promet (Zagreb), 2005
Electronic journals have become an inevitable source ofscientific information. Their advantage, in relation to theprinted journals results from the characteristics of the media:they are available to all the interested users at the same time, beforethan ...
Mira Bačić, Darko Furač, Vesna Golubović   +2 more
doaj   +1 more source