Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
International Conference on Advanced Computing and Applications, 2019 semanticscholar +2 more sources
Natural Language Information Retrieval Tomek Strzalkowski (editor) Dordrecht: Kluwer Academic Publishers (Text, speech and language technology series, edited by Nancy Ide and Jean Véronis, volume 7), 1999, xxv+384 pp; hardbound, ISBN 0-7923-5685-3, $144.00, £84, Dfl 240.00 [PDF]
, 2000 Simon Corston-Oliver
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Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Advances in Information Retrieval: Recent Research from the Center for Intelligent Information Retrieval W. Bruce Croft (editor) (University of Massachusetts, Amherst) Dordrecht: Kluwer Academic Publishers (The Kluwer international series on information retrieval, edited by W. Bruce Croft), 2000, xv+306 pp; hardbound, ISBN 0-7923-7812-1, $99.50, £68.75, Dfl 230.00 [PDF]
, 2001 Sanda M. Harabagiu
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Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Relationships in the Organization of Knowledge Carol A. Bean and Rebecca Green (editors) (University of Tennessee and University of Maryland) Dordrecht: Kluwer Academic Publishers (Information science and knowledge management series, edited by J. Mackenzie Owen, volume 2), 2001, ix+232 pp; hardbound, ISBN 0-7923-6813-4, $97.00, £61.00, €90.00 [PDF]
, 2002 Gregory Grefenstette
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Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source