Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
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The Creation-Story of Genesis I: a Sumerian Theogony and Cosmogony. By DrHugo Radau. pp. xv and 70. (Chicago, Open Court Publishing Co.; London, Kegan Paul, Trench, Trübner, & Co., 1892.) [PDF]
T. G. Pinches
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In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen+17 more
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Chemical Abstracts . Published by the American Chemical Society. Edited by William A. Noyes and C. A. Waters, with the cooperation of a large staff of assistant editors and abstractors. Published semi-monthly. Easton, Pa., Chemical Publishing Co. Vol. I., No. 1, January 1, 1907. Price, $6.00 per annum. [PDF]
Marston Taylor Bogert
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Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane+16 more
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Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien+7 more
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The Problem of Space in Jewish Medieval Philosophy. Israel Isaac Efros, Ph.D. Columbia University Press, 1917. Pp. viii, 125. $1.50. - Saadia's Polemic against Hiwi Al-Balkhi. Israel Davidson. Published by the Jewish Theological Seminary of America. A Fragment edited from a Genizah MS., with a Facsimile. New York. 1915. Pp. 104. $1.00. - Scrolls. Essays on Jewish History and Literature and Kindred Subjects. Gotthard Deutsch. 2 vols. Bloch Publishing Co.New York. 1917. [PDF]
Joshua Bloch
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren+4 more
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