Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
PUBLISHING AND PUBLISHING WORK
, 2023 This article is about publishers and their types. This article provides detailed information about the types of publishers such as press, electronic publishers, radio and TV channels. The tasks of publishers, the advantages they bring to society and the important points affecting their development are highlighted.
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Reviews : Devine, E. T. Report on the Desirability of Establishing an Employment Bureau in the City of New York. Pp. 238. Price, $I.25. New York : Charities Publishing Company, I909 [PDF]
, 1909 George B. Mangold
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
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Experiments on the Generation of Insects . By Francesco Redi. Translated from the Italian edition of 1688 by Mab Bigelow. 8vo, pp. 160, illustrated. Chicago, The Open Court Publishing Co. 1909. [PDF]
, 1910 William A. Locy
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Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
The Other Side of Evolution: 'The Other Side of Evolution, an Examination of its Evidences,' by Rev. Alexander Patterson, author of, etc., with an introduction by George Frederick Wright, D.D., LL.D., F.G.S.A. The Winona Publishing Co., Chicago, Ills. Winona Lake, Ind. [PDF]
, 1906 Carl H. Eigenmann
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
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