TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
The Other Side of Evolution: 'The Other Side of Evolution, an Examination of its Evidences,' by Rev. Alexander Patterson, author of, etc., with an introduction by George Frederick Wright, D.D., LL.D., F.G.S.A. The Winona Publishing Co., Chicago, Ills. Winona Lake, Ind. [PDF]
, 1906 Carl H. Eigenmann
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Physicists Thriving with Paperless Publishing
, 2000 The Stanford Linear Accelerator Center (SLAC) and Deutsches Elektronen Synchrotron (DESY) libraries have been comprehensively cataloguing the High Energy Particle Physics (HEP) literature online since 1974. The core database, SPIRES-HEP, now indexes over
O'Connell, Heath B.
core
`Electronic Publishing' -- Practice and Experience [PDF]
, 1990 Electronic Publishing -- Origination, Dissemination and Design (EP-odd) is an academic journal which publishes refereed papers in the subject area of electronic publishing.
Brailsford, David F. +2 more
core
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Purulent Nasal Discharges: their Diagnosis and Treatment. By Tilley Herbert, M.D., B.S. Lond., F.R.C.S. Eng. The Medical Publishing Company, Ltd. [PDF]
, 1900 Dandas Grant
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Frontiers in PsychologyIntroductionWith the increasing number of children’s publications that integrate new media technologies in the global publishing community, understanding the adoption and use of these publications from a child’s perspective is of great significance for ...
Jiayong Cui +7 more
doaj +1 more source
The Microscope and Microscopical Methods . By Simon Henry Gage. Sixth edition. Rewritten, greatly enlarged. Comstock Publishing Company, Ithaca, New York. 1896. Octavo; pp. xii+237; 165 figures, 1 plate. [PDF]
, 1897 Henry B. Ward
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source