Results 51 to 60 of about 5,056,142 (323)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The strategy for the development of electronic publishing in small markets
Libellarium: Journal for the Research of Writing, Books, and Cultural Heritage Institutions, 2014 This paper analyses technological trends which affect the business models in the publishing industry and create innovative publishing products which reflect the reader's needs in the digital environment.
Ivona Despot, Tomislav Jakopec
doaj +1 more source
Adam Bede, realism, the past, and readers in 1859 [PDF]
, 2020 This article gives an account of the immediate publication context of George Eliot’s first novel, Adam Bede, in terms of competing opportunities for leisure, anxieties about the reading of fiction, the publishing industry, and the social and political ...
Marshall, Gail
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Building a Successful Publishing Company [PDF]
, 2014 In the present book publishing industry, it is becoming increasingly difficult for traditional book publishing companies to compete and adapt due to the changing structure of the industry.
Buechner, Joshua M
core +1 more source
, 2019 This landscape analysis was produced by SPARC in response to the growing trend of commercial acquisition of critical infrastructure in our institutions. It is intended to provide a comprehensive look at the current players in this arena, their strategies
Claudio Aspesi +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Demand Distribution Dynamics in Creative Industries: the Market for Books in Italy [PDF]
We study the distribution dynamics of the demand for books in Italy. We find that for each of three broad sub-markets in which the book publishing industry can be classified Italian novels, foreign novels and essays sales over a three-year sample can be ...
Antonello E. Scorcu +2 more
core +3 more sources