Results 71 to 80 of about 13,047,952 (281)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Publishing and innovation : disruption in the Chinese ebook industry
, 2019 Is digital publishing leading to a paradigm shift or only replicating the print publishing systems in digital garb? This appears to be a key concern of the Chinese publishing industry in the internet age.
Ren, Xiang (Tony) (R18853)
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Children's publishing in Turkey in numbers [PDF]
, 2018 The publishing industry in Turkey has caught a stable and rapid growth in Turkey, with the rate in children’s publishing increasingly rising. Erdem Publishing Group Editor-in-Chief Melike Günyüz evaluated the children’s publishing industry in ...
Günyüz, Melike
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The book publishing industry in Japan and the UK: corporate philosohpy/objectives, behaviour and market structure [PDF]
A number of prominent publishers in the UK and US have become parts of globalized media groups. In Japan, by contrast, they have neither been absorbed into media groups nor become globalized businesses.
Hugh Whittaker, Dai Miyamato
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Why Are Scholarly Journals Costly even with Electronic Publishing? [PDF]
, 2009 Journal literature has long played a prominent role in the scholarly communication chain. In recent decades, however, the scholarly communication system has been facing a crisis due to the ever-escalating costs of journals.
Galyani-Moghaddam, Golnessa
core +1 more source
Critical examination of the IEET measurement instrument for the assessment of textbook quality
Ekonomski Vjesnik, 2018 As is the case in other sectors of the creative industry, the publishing industry also evaluates its projects finalized in the form of products and services in the market of creative contents.
Ivana Ljevak Lebeda +2 more
doaj
Business Intelligence Challenges for Independent Game Publishing
International Journal of Computer Games Technology, 2020 With the continuous development of the game industry, research in the game field is also deepening. Many interdisciplinary areas of knowledge and theory have been used to promote the development of the game industry.
Yanhui Su +2 more
doaj +1 more source