Lactate Dehydrogenase Inhibition Reverts the Fatty Acid‐Induced Neurotoxic Phenotype of Astrocytes
Glia, Volume 74, Issue 3, March 2026.ALS models display increased LD accumulation. LD accumulation is linked to a neurotoxic phenotype in astrocytes. Lactate dehydrogenase inhibition reverts LD accumulation in ALS astrocytes. ABSTRACT Astrocytes are central to lipid metabolism in the central nervous system.
Daniel Esteve +5 more
wiley +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Global burden of disease analysis and projections of ischemic stroke linked to inadequate polyunsaturated fatty acid intake in older women (1990-2021). [PDF]
Front NutrLuo Y, Zhu G, Tan Q, Lin Y, Yang J.
europepmc +1 more source
Remodelling of primary human CD4+ T cell plasma membrane order by n-3 PUFA
British Journal of Nutrition, 2017 Yang-Yi Fan +8 more
semanticscholar +1 more source
Band‐Selective IR PRESS for Brain Tumor Spectroscopy Allows Robust Detection of Lactate
NMR in Biomedicine, Volume 39, Issue 3, March 2026.Lactate quantification by MRS is hindered by lipid signal overlap at 1.3 ppm, frequently forcing the use of long echo times that suppress other metabolites. We developed SPIR‐PRESS, a selective inversion recovery technique that suppresses lipids while preserving metabolite sensitivity.
Shun Kishimoto +12 more
wiley +1 more source
Omega-3 Polyunsaturated Fatty Acids and Adipose Tissue Inflammation in Humans: A Scoping Review. [PDF]
Nutr RevChon JE +6 more
europepmc +1 more source
Prokaryotic PfaB is a terminal acyltransferase that determines the final PUFA product
Protein Science, Volume 35, Issue 3, March 2026.Abstract Omega‐3 polyunsaturated fatty acids (PUFAs) are essential for human health due to their numerous beneficial biological properties. These compounds are synthesized in marine bacteria and eukaryotic microalgae by PUFA megasynthases (Pfas), which are evolutionarily related to fatty acid synthases (FAS) and polyketide synthases (PKS). In FAS, PKS,
Nahuel Lofeudo +5 more
wiley +1 more source
From Raw to Cooked: Proximate Composition, Fatty Acids and Fat-Soluble Vitamins in Bluefish (<i>Pomatomus saltatrix</i>) from the Black Sea. [PDF]
FoodsPanayotova V +10 more
europepmc +1 more source