Results 221 to 230 of about 114,514 (356)

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

open access: yesCancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah   +3 more
wiley   +1 more source

The association between oral health clusters and oral health‐related quality of life: A population‑based study of 5‑yr‑old children

open access: yesEuropean Journal of Oral Sciences, EarlyView.
Abstract This study aimed to describe oral health clusters that combine dental conditions and perceived oral health and to examine the association of oral health indicators and their clusters with oral health‐related quality of life (OHRQoL) in 5‐yr‐old children.
Pedro Henrique Duarte França de Castro   +2 more
wiley   +1 more source

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

open access: yesThe FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump   +10 more
wiley   +1 more source

Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults.

open access: yesAmerican Journal of Clinical Nutrition, 2015
Gordon I. Smith   +5 more
semanticscholar   +1 more source

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