MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
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Phagocytosis of Primary Human Macrophages is Elevated by Ex Vivo Supplementation with n-3 PUFA. [PDF]
Kirchhoff R, Chromik MA, Schebb NH.
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Fatty acid in the intramuscular and abdominal fat of chickens: their composition, deposition, regulation and impact on flavor. [PDF]
Zou J, Li H, Zhang X.
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Abstract This study aimed to describe oral health clusters that combine dental conditions and perceived oral health and to examine the association of oral health indicators and their clusters with oral health‐related quality of life (OHRQoL) in 5‐yr‐old children.
Pedro Henrique Duarte França de Castro +2 more
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Effect of polyunsaturated fatty acids supplementation on nutritional status in patients with pancreatic cancer: a systematic review and meta-analysis. [PDF]
Liu G +7 more
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Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump +10 more
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Integrated metatranscriptomics identifies Lachnospiraceae as keystone taxa regulating rumen biohydrogenation and milk ω-6/ω-3 polyunsaturated fatty acids ratio in dairy cows. [PDF]
Zhang H +9 more
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Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults.
Gordon I. Smith +5 more
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