Results 121 to 130 of about 802,075 (353)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Experimental And Numerical Investigations On Uplift Behaviour Of Plate Anchors In Cohesionless Soil [PDF]
, 2013 In this study, series of small scale laboratory pull-out tests were conducted on anchors embedded in sand. Model tests were performed in a test box. The effects of embedment ratioof anchor plates and relative density of sand on uplift capacity behaviour ...
Mustafa Laman, Selcuk Bildik
core
Model coupling friction and adhesion for steel-concrete interfaces
, 2009 The interface behaviour between steel and concrete, during pull-out tests, is numerically investigated using an interface model coupling adhesion and Coulomb friction. This model, first developed by Raous, Cang\'emi, Cocou and Monerie (RCCM), is based on
Karray, M'hamed Ali, Raous, Michel
core +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Bond Behaviors of Epoxy Coated Reinforcements Using Direct Pull-out Test [PDF]
, 2017 Jee-Sang Kim, Sang Hyun Lee
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Pull-Out Resistance Capacity of a New Perfobond Shear Connector for Steel Pile Cap Strengthening
Advances in Materials Science and Engineering, 2016 This study proposes a new type of the perfobond shear connector, which can be used to strengthen the steel pile cap embedded into the structure foundation, and evaluates its pull-out resistance capacity by performing a test on ten specimens.
Young-Ho Kim +3 more
doaj +1 more source
Determination of acceptance criteria for prestressing strand in pre-tensioned applications [PDF]
Doctor of PhilosophyDepartment of Civil EngineeringKyle A. RidingASTM recently adopted the Standard Test Method for Evaluating Bond of Seven-Wire Steel Prestressing Strand as ASTM A1081, a pull-out test procedure developed for verifying the ability of ...
Polydorou, Thomaida
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source