Results 71 to 80 of about 15,600,345 (296)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ, 2018 Tires are considered important components of the vehicle by which the vehicle can move on the road. The continuous development in the transportation requires improving tires to suit the modern requirements of the transportation.
Ahmed A. Kadhem +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Interfacial Characterization by Pull-Out Test of Bamboo Fibers Embedded in Poly(Lactic Acid)
Fibers, 2018 In this work, the apparent shear strength at the interface between a bamboo fiber and the surrounding poly(lactic acid) (PLA) matrix is quantified. A method for processing pull-out test samples within a controlled embedded length is proposed and the ...
Quentin Viel +4 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Tensile Performance of Perforated IPE Connectors within Composite Beams
Revista Ingeniería de ConstrucciónThis paper examines the performance of IPE perforated shear connectors, emphasizing their role in maintaining the structural integrity of composite beams.
Boursas Farid +3 more
doaj +1 more source
Bond behavior and assessment of design ultimate bond stress of normal and high strength concrete
Alexandria Engineering Journal, 2014 The aim of this work is to assess the ultimate bond stress of normal and high strength concrete. This study contains two phases. The first phase included the studied bond behavior using two different models. In the first model, single pull-out test (SPOT)
Ahmed M. Diab +3 more
doaj +1 more source