Results 71 to 80 of about 101,539 (261)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Power Pull: an unconditionally stable active Load-Pull measurement system
, 1998 For today's communication circuits optimum operational conditions for almost every Tx power amplifier is one of the most important parameters. Only this will offer maximum power added efficiency and output power. For the experimental determination of these conditions load-pull measurements are the best solution. To compensate losses of the setup for on-
Koether, D., Sporkmann, Th.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Bottleneck Oriented Card-Based Production Control for Push Repetitive Manufacturing Systems
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2013 One of the major problems of the push Repetitive Manufacturing Systems (RMS) is the Work In Process (WIP) buildups between the stations due to the push nature of the flow of material. Card-based pull or push-pull production control systems offered smooth
Muhammad Haris AZIZ +4 more
doaj +1 more source
Towards Keyword-based Pull Recommendation Systems
Proceedings of the 18th International Conference on Enterprise Information Systems, 2016 Due to the high availability of data, users are frequently overloaded with a huge amount of alternatives when they need to choose a particular item. This has motivated an increased interest in research on recommendation systems, which filter the options and provide users with suggestions about specific elements (e.g., movies, restaurants ...
María del Carmen Rodríguez-Hernández +3 more
openaire +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
California Agriculture, 1966 SPRINKLER IRRIGATION for tree crops in the San Joaquin Valley has increased rapidly during the past ten years, particularly in areas planted to citrus. While no exact figures are obtainable, it is estimated that more than 20,000 of the 100,000 acres in ...
R Schade
doaj
Trees, Forests and PeoplePush-pull technology is a companion cropping system whose success in soil fertility improvement and management of agricultural pests has been established in cereal-based systems.
Elisheba Amolo Imbaya +3 more
doaj +1 more source