Results 101 to 110 of about 445,623 (380)

Large Language Models with Retrieval-Augmented Generation for Zero-Shot Disease Phenotyping [PDF]

arXiv, 2023
Identifying disease phenotypes from electronic health records (EHRs) is critical for numerous secondary uses. Manually encoding physician knowledge into rules is particularly challenging for rare diseases due to inadequate EHR coding, necessitating review of clinical notes.
arxiv  

The revolution of pulmonary arterial hypertension [PDF]

European Respiratory Review, 2016
If there has been a revolution in medical therapy in recent decades, it is the treatment of PAH http://ow.ly ...
openaire   +5 more sources

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Advanced Science, EarlyView.
Aortic dissection (AD) is accompanied by a decrease in CCDC80 in vascular smooth muscle cells (VSMCs). CCDC80 can interact with JAK2, and VSMC‐specific CCDC80 deficiency accelerates the progression of AD by activating the JAK2/STAT3 pathway involved in regulating the phenotype switching and function of VSMCs.
Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen   +18 more
wiley   +1 more source

Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation [PDF]

, 2018
This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a control and hypoxia induced hypertensive mouse. We use local and global sensitivity and correlation analysis to determine parameters that can be inferred from the model and ...
arxiv   +1 more source

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature Communications, 2018
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-β pathway, particularly the bone morphogenetic protein type 2 receptor (BMPR2), underlies most ...
S. Gräf, M. Haimel, M. Bleda, C. Hadinnapola, L. Southgate, L. Southgate, Wei Li, J. Hodgson, Bin Liu, R. Salmon, M. Southwood, R. Machado, Jennifer M. Martin, C. Treacy, C. Treacy, Katherine Yates, L. Daugherty, O. Shamardina, Deborah Whitehorn, Simon Holden, M. Aldred, H. Bogaard, Colin Church, G. Coghlan, R. Condliffe, P. Corris, C. Danesino, M. Eyries, Henning Gall, Stefano Ghio, H. Ghofrani, H. Ghofrani, J. S. R. Gibbs, B. Girerd, A. Houweling, Luke Howard, Marc Humbert, D. Kiely, Gabor Kovacs, R. Ross, S. Moledina, D. Montani, M. Newnham, Andrea Olschewski, H. Olschewski, A. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, L. Scelsi, Werner Seeger, F. Soubrier, D. Stein, J. Suntharalingam, E. Swietlik, M. Toshner, D. A. Heel, A. Noordegraaf, Q. Waisfisz, J. Wharton, S. J. Wort, W. Ouwehand, Nicole Soranzo, Nicole Soranzo, A. Lawrie, P. Upton, Martin R. Wilkins, R. Trembath, N. Morrell   +68 more
semanticscholar   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Reduced RVSWI Is Associated With Increased Mortality in Connective Tissue Disease Associated Pulmonary Arterial Hypertension

Frontiers in Cardiovascular Medicine, 2020
Rationale: The prognosis of pulmonary arterial hypertension is poor, especially amongst patients with connective tissue disease related pulmonary arterial hypertension.
Katharine R. Clapham, Kristin B. Highland, Youlan Rao, Wassim H. Fares   +3 more
doaj   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries [PDF]

, 2019
Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made subject-specific modelling of the cardiovascular system a feasible task, which is particularly important in the case of pulmonary hypertension (PH), which requires a combination
arxiv   +1 more source

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

European Respiratory Journal, 2019
Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent data from normal
G. Simonneau, D. Montani, D. Celermajer, C. Denton, M. Gatzoulis, M. Krowka, Paul G. Williams, R. Souza   +7 more
semanticscholar   +1 more source