Results 121 to 130 of about 560,791 (351)

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang   +5 more
wiley   +1 more source

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

open access: yesNature Communications, 2019
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of cardiopulmonary units. No cure is currently available due to an incomplete understanding of vascular remodeling.
Yongting Luo   +9 more
semanticscholar   +1 more source

Vascular Changes During Resolution Of Pulmonary Arterial Hypertension [PDF]

open access: bronze, 1981
Clarence A. Rawlings   +2 more
openalex   +1 more source

Changes in hemodynamics of pulmonary artery using Flowire in a canine model of acute pulmonary thromboembolism

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study investigated changes in pulmonary artery hemodynamics using a Flowire catheter and evaluated the accuracy of Doppler echocardiography in dogs with acute pulmonary thromboembolism (PTE). Ten healthy beagles were anesthetized, and acute pulmonary hypertension (PH) was induced by injecting 300‐μm dextran microspheres.
Tomohiko Yoshida   +3 more
wiley   +1 more source

Understanding pulmonary arterial hypertension

open access: yesNursing Management (Springhouse), 2004
New therapies improve the management of pulmonary arterial hypertension.
openaire   +6 more sources

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

open access: yesThe Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna   +15 more
wiley   +1 more source

Activin A–Activated ALK4 Induces Pathogenic Th17‐Involved Endothelial–Mesenchymal Transition in Systemic Lupus Erythematosus–Associated Pulmonary Arterial Hypertension

open access: yesArthritis &Rheumatology, EarlyView.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE has not been clarified.
Shuliang Jing   +9 more
wiley   +1 more source

B cells and systemic sclerosis interstitial lung disease

open access: yesArthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman   +2 more
wiley   +1 more source

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