Results 121 to 130 of about 423,899 (348)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

European Respiratory Journal, 2019
Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent data from normal
G. Simonneau, D. Montani, D. Celermajer, C. Denton, M. Gatzoulis, M. Krowka, Paul G. Williams, R. Souza   +7 more
semanticscholar   +1 more source

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini, Dean, Afshan, Hood, Katie, Johansen, Anne Katrine Z., Loughlin, Lynn, MacLean, Margaret R., Morecroft, Ian, Nilsen, Margaret, Touyz, Rhian M., White, Kevin   +9 more
core   +1 more source

Neutrophil–Endothelium Interaction Mediated by S100A9 Promotes Pulmonary Vascular Remodeling During Pulmonary Hypertension

Advanced Science, EarlyView.
This study investigates the critical mechanisms underlying pulmonary hypertension progression, with a focus on the novel role of neutrophil‐derived S100A9 in endothelial dysfunction‐mediated pulmonary vascular remodeling. By integrating human lung samples, multi‐omics analyses, animal models, and mechanistic in vitro studies, it is revealed that how ...
Yu Guo, Zhenqiang Gao, Ruoyang Zhang, Huanyu Long, Muzhi Zhang, Lin Liu, Zhe An, Yuezhe Shi, Ye Cui, Yufeng Jia, Lei Wang, Ying Sun, Jie Liu, Wei Wang   +13 more
wiley   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Long-term therapy of interferon-alpha induced pulmonary arterial hypertension with different PDE-5 inhibitors: a case report

Cardiovascular Ultrasound, 2005
background Interferon alpha2 is widely used in hepatitis and high-risk melanoma. Interferon-induced pulmonary arterial hypertension as a side effect is rare.
Baumann Gert, Sterry Wolfram, Eddicks Stephan, Hofmann Maja A, Borges Adrian C, Kiecker Felix, Jochmann Nicoline, Trefzer Uwe   +7 more
doaj   +1 more source

Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model

Pulmonary Circulation, 2020
The pathogenesis of pulmonary arterial hypertension is closely associated with dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition and function were reported in a pulmonary arterial hypertension experimental animal ...
T. Sanada, Koji Hosomi, Hiroki Shoji, Jonguk Park, A. Naito, Yumiko Ikubo, Asako Yanagisawa, Takayuki Kobayashi, H. Miwa, Rika Suda, S. Sakao, K. Mizuguchi, J. Kunisawa, N. Tanabe, K. Tatsumi   +14 more
semanticscholar   +1 more source

CT-measured pulmonary artery diameter as an independent predictor of pulmonary hypertension in cystic fibrosis [PDF]

, 2018
Purpose: The role of computed tomography (CT) scan, as a promising prognostic imaging modality in cystic fibrosis(CF), has been widely investigated, focusing on parenchymal abnormalities.
Aghahosseini, Farahnaz, Bakhshayeshkaram, Mehrdad, Hassanzad, Maryam, Jamaati, Hamid Reza, Kahkooei, Shahram, Salehi, Yalda, Vaezi, Fatemeh, Velayati, Ali Akbar   +7 more
core   +1 more source

Pulmonary Artery Denervation for Pulmonary Artery Hypertension

JACC: Cardiovascular Interventions, 2015
While the seminal advance in the treatment of pulmonary artery hypertension (PAH) over the past 2 decades has been pharmacological targeting of dysfunctional endothelium-derived pathways that contribute to the characteristic vascular remodeling of this condition irrespective of etiology [(1)][1],
openaire   +3 more sources

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source