Results 51 to 60 of about 445,623 (380)
Right ventriculo–pulmonary arterial uncoupling and poor outcomes in pulmonary arterial hypertension
Pulmonary Circulation, 2020 Right ventricular function critically affects the prognosis of patients with pulmonary arterial hypertension. We aimed to analyze the prognostic value of right ventricular indices calculated using magnetic resonance imaging and right heart ...
Toshitaka Nakaya +8 more
doaj +1 more source
PHT-bot: Deep-Learning based system for automatic risk stratification of COPD patients based upon signs of Pulmonary Hypertension [PDF]
Proc. SPIE 10950, Medical Imaging 2019: Computer-Aided Diagnosis,
109500O, 2019 Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality worldwide. Identifying those at highest risk of deterioration would allow more effective distribution of preventative and surveillance resources. Secondary pulmonary hypertension is a manifestation of advanced COPD, which can be reliably diagnosed by the main ...
arxiv +1 more source
Sildenafil citrate therapy for pulmonary arterial hypertension.
New England Journal of Medicine, 2005 BACKGROUND Sildenafil inhibits phosphodiesterase type 5, an enzyme that metabolizes cyclic guanosine monophosphate, thereby enhancing the cyclic guanosine monophosphate-mediated relaxation and growth inhibition of vascular smooth-muscle cells, including ...
N. Galiè +12 more
semanticscholar +1 more source
Cellular senescence impairs the reversibility of pulmonary arterial hypertension
Science Translational Medicine, 2020 The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis. Reversing maladaptive remodeling Pathologic vascular remodeling of pulmonary arterial hypertension (PAH ...
D. E. van der Feen +19 more
semanticscholar +1 more source
Pulmonary Circulation, 2022 Treatment for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension in Latin America differs between countries, with regard to disease etiology, health insurance coverage, and drug availability.
Mauricio Orozco‐Levi +11 more
doaj +1 more source
Application and reduction of a nonlinear hyperelastic wall model capturing ex vivo relationships between fluid pressure, area and wall thickness in normal and hypertensive murine left pulmonary arteries [PDF]
arXiv, 2022 Pulmonary hypertension is a cardiovascular disorder manifested by elevated arterial blood pressure together with vessel wall stiffening and thickening due to alterations in collagen, elastin and smooth muscle cells. Hypoxia-induced (type 3) pulmonary hypertension can be studied in animals exposed to a low oxygen environment for prolonged time periods ...
arxiv
Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Antioxidants and Redox Signaling, 2020 Endothelial-to-Mesenchymal transition (EndMT) is a process which encompasses extensive transcriptional reprogramming of activated endothelial cells leading to a shift towards mesenchymal cellular phenotypes and functional responses. Initially observed in
A. Gorelova, M. Berman, I. Al Ghouleh
semanticscholar +1 more source
Circulation, 2020 Supplemental Digital Content is available in the text. Background: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that enables coronavirus disease 2019 (COVID ...
Hui Shen +14 more
semanticscholar +1 more source
Predicting Pulmonary Hypertension by Electrocardiograms Using Machine Learning [PDF]
arXiv, 2023 Pulmonary hypertension (PH) is a condition of high blood pressure that affects the arteries in the lungs and the right side of the heart (Mayo Clinic, 2017). A mean pulmonary artery pressure greater than 25 mmHg is defined as Pulmonary hypertension.
arxiv
Obesity, estrogens and adipose tissue dysfunction – implications for pulmonary arterial hypertension
Pulmonary Circulation, 2020 Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and ...
K. Mair, R. Gaw, M. MacLean
semanticscholar +1 more source