Incident pulmonary arterial hypertension associated with Bosutinib
Pulmonary Circulation, 2020 Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug-induced pulmonary arterial hypertension.
Shaun Yo +3 more
doaj +1 more source
Quantification of Pulmonary Arterial Wall Distensibility Using Parameters Extracted from Volumetric Micro-CT Images [PDF]
, 1999 Stiffening, or loss of distensibility, of arterial vessel walls is among the manifestations of a number of vascular diseases including pulmonary arterial hypertension.
Dawson, Christopher A +3 more
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Endothelin-1 Predicts Hemodynamically Assessed Pulmonary Arterial Hypertension in HIV Infection. [PDF]
, 2016 BackgroundHIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. ET-1 is a robust vasoconstrictor and key mediator of pulmonary vascular homeostasis.
AH Chester +51 more
core +8 more sources
Impact of the updated hemodynamic definitions on diagnosis rates of pulmonary hypertension
Pulmonary Circulation, 2020 We evaluated whether updated pulmonary hypertension definitive criteria proposed in sixth World Symposium on Pulmonary Hypertension had an impact on diagnosis of overall pulmonary hypertension and pre-capillary and combined pre- and post-capillary ...
Seda Tanyeri +15 more
doaj +1 more source
Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension [PDF]
, 2014 Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and ...
Boin, Francesco +8 more
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Clinical heterogeneity of Pulmonary Arterial Hypertension associated with variants in TBX4.
PLoS ONE, 2020 BACKGROUND:The knowledge of hereditary predisposition has changed our understanding of Pulmonary Arterial Hypertension. Genetic testing has been widely extended and the application of Pulmonary Arterial Hypertension specific gene panels has allowed its ...
Ignacio Hernandez-Gonzalez +15 more
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Animal Models of Pulmonary Arterial Hypertension and Their Application in Drug Research
Shiyan dongwu yu bijiao yixue, 2023 Pulmonary arterial hypertension is a clinical syndrome characterized by pulmonary vascular remodeling causing increased vascular resistance, which will lead to right heart failure and even death if left untreated.
YU Jiahui, GONG Qian, ZHUANG Lenan
doaj +1 more source
Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension
Pulmonary Circulation, 2019 Pulmonary arterial hypertension is a severe disease for which diagnosis often is delayed. Matrix metalloproteinases have been suggested to play a role in vascular remodeling and pulmonary hypertension development. Our aim was therefore to investigate the
Mattias Arvidsson +3 more
doaj +1 more source
Transcription factors and potential therapeutic targets for pulmonary hypertension
Frontiers in Cell and Developmental Biology, 2023 Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary arterial smooth muscle cells (PASMCs), dysfunction of pulmonary arterial ...
Liu Yang +5 more
doaj +1 more source
Dobutamine stress MRI in pulmonary hypertension: relationships between stress pulmonary artery relative area change, RV performance, and 10-year survival [PDF]
, 2017 In pulmonary hypertension (PH), right ventricular (RV) performance determines survival. Pulmonary artery (PA) stiffening is an important biomechanical event in PH and also predicts survival based on the PA relative area change (RAC) measured at rest ...
Bellofiore, Alessandro +6 more
core +1 more source