Results 21 to 30 of about 194,414 (305)

Incident pulmonary arterial hypertension associated with Bosutinib

Pulmonary Circulation, 2020
Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug-induced pulmonary arterial hypertension.
Shaun Yo, John Thenganatt, Jeffrey Lipton, John Granton   +3 more
doaj   +1 more source

Genetics of Pulmonary Arterial Hypertension [PDF]

Seminars in Respiratory and Critical Care Medicine, 2009
Tremendous progress has been made in understanding the genetics of pulmonary arterial hypertension (PAH) since its description in the 1950s as a primary disorder of the pulmonary vasculature. Heterozygous germline mutations in the gene coding bone morphogenetic receptor type 2 (BMPR2) are detectable in the majority of cases of heritable PAH, and in ...
Eric D, Austin, James E, Loyd, John A, Phillips   +2 more
openaire   +3 more sources

Animal Models of Pulmonary Arterial Hypertension and Their Application in Drug Research

Shiyan dongwu yu bijiao yixue, 2023
Pulmonary arterial hypertension is a clinical syndrome characterized by pulmonary vascular remodeling causing increased vascular resistance, which will lead to right heart failure and even death if left untreated.
YU Jiahui, GONG Qian, ZHUANG Lenan
doaj   +1 more source

Impact of the updated hemodynamic definitions on diagnosis rates of pulmonary hypertension

Pulmonary Circulation, 2020
We evaluated whether updated pulmonary hypertension definitive criteria proposed in sixth World Symposium on Pulmonary Hypertension had an impact on diagnosis of overall pulmonary hypertension and pre-capillary and combined pre- and post-capillary ...
Seda Tanyeri, Ozgur Y. Akbal, Berhan Keskin, Aykun Hakgor, Ali Karagoz, Hacer Ceren Tokgoz, Cem Dogan, Zubeyde Bayram, Seyhmus Kulahcioglu, Emrah Erdogan, Ismail Balaban, Dogancan Ceneli, Rezzan Deniz Acar, Ibrahim H. Tanboga, Nihal Ozdemir, Cihangir Kaymaz   +15 more
doaj   +1 more source

The role of the right ventricle in pulmonary arterial hypertension [PDF]

, 2011
Although changes in the pulmonary vasculature are the primary cause of pulmonary arterial hypertension (PAH), severity of symptoms and survival are strongly associated with right ventricular function, and right heart failure is the main cause of death in
A. Vonk Noordegraaf, Vonk Noordegraaf, A., N. Galiè, Galie, N.   +3 more
core   +1 more source

Pulmonary Arterial Hypertension

The American Journal of the Medical Sciences, 2008
It is important for the general internist to maintain a high degree of suspicion for pulmonary hypertension in appropriate cases. This article reviews the definition and classification of pulmonary hypertension, epidemiology and risk factors, signs and symptoms, diagnostic approach, and treatment strategies.
Chin, Kelly M., Rubin, Lewis J.
openaire   +4 more sources

Clinical heterogeneity of Pulmonary Arterial Hypertension associated with variants in TBX4.

PLoS ONE, 2020
BACKGROUND:The knowledge of hereditary predisposition has changed our understanding of Pulmonary Arterial Hypertension. Genetic testing has been widely extended and the application of Pulmonary Arterial Hypertension specific gene panels has allowed its ...
Ignacio Hernandez-Gonzalez, Jair Tenorio, Julian Palomino-Doza, Amaya Martinez Meñaca, Rafael Morales Ruiz, Mauro Lago-Docampo, María Valverde Gomez, Javier Gomez Roman, Ana Belén Enguita Valls, Carmen Perez-Olivares, Diana Valverde, Joan Gil Carbonell, Elvira Garrido-Lestache Rodríguez-Monte, Maria Jesus Del Cerro, Pablo Lapunzina, Pilar Escribano-Subias   +15 more
doaj   +1 more source

Repurposing of medications for pulmonary arterial hypertension

, 2020
This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory ...
Spiekerkoetter, Edda, Bogaard, Harm Jan, Toshner, Mark, Georg Hansmann, Edda Spiekerkoetter, Harm Bogaard, Hansmann, Georg, Kurt W. Prins, Sylvia Nikkho, Nikkho, Sylvia, Prins, Kurt W., Mark Toshner   +11 more
core   +1 more source

Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension

Pulmonary Circulation, 2019
Pulmonary arterial hypertension is a severe disease for which diagnosis often is delayed. Matrix metalloproteinases have been suggested to play a role in vascular remodeling and pulmonary hypertension development. Our aim was therefore to investigate the
Mattias Arvidsson, Abdulla Ahmed, Habib Bouzina, Göran Rådegran   +3 more
doaj   +1 more source

Transcription factors and potential therapeutic targets for pulmonary hypertension

Frontiers in Cell and Developmental Biology, 2023
Pulmonary hypertension (PH) is a refractory and fatal disease characterized by excessive pulmonary arterial cell remodeling. Uncontrolled proliferation and hypertrophy of pulmonary arterial smooth muscle cells (PASMCs), dysfunction of pulmonary arterial ...
Liu Yang, Naifu Wan, Fanpeng Gong, Xianfeng Wang, Lei Feng, Guizhu Liu   +5 more
doaj   +1 more source