Results 11 to 20 of about 1,381,406 (265)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex-Differential Proteins and Candidate Therapeutic Targets. [PDF]

Adv Sci (Weinh)
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Lin X, Zhang Y, Pu Y, Liu D, Lei T, Ma K, He Q, Dou Z, Liu Y, Liu D, He Y, Wang Y, Zheng X, Ma Y, Zhou J, Zhai W, Su B, Chen L, Li S.   +18 more
europepmc   +2 more sources

Repurposing of medications for pulmonary arterial hypertension [PDF]

, 2020
This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory ...
Spiekerkoetter, Edda, Bogaard, Harm Jan, Toshner, Mark, Georg Hansmann, Edda Spiekerkoetter, Harm Bogaard, Hansmann, Georg, Kurt W. Prins, Sylvia Nikkho, Nikkho, Sylvia, Prins, Kurt W., Mark Toshner   +11 more
core   +4 more sources

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources

Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood [PDF]

, 2005
BACKGROUND: Pulmonary arterial hypertension (PAH) is a potentially fatal vasculopathy that can develop at any age. Adult-onset disease has previously been associated with mutations in BMPR2 and ALK-1.
Haworth, SG, Berger, R; id_orcid, Aldred, M A, Morrell, NW, Harrison, RE, Morrell, Nicholas W., Morrell, N W, Mache, CJ, Haworth, S G, Trembath, R C, Mache, Christoph J., Aldred, MA, Trembath, RC, Berger, Rolf, Aldred, Micheala A., Berger, R, Tulloh, R, Harrison, R E, Harrison, Rachel E., Haworth, Sheila G., Mache, C J, Trembath, Richard C., Tulloh, Robert   +22 more
core   +1 more source

Clinical implications of partial anomalous pulmonary venous connection: a rare cause of severe pulmonary arterial hypertension

Pulmonary Circulation, 2020
Isolated partial anomalous pulmonary venous connection (PAPVC) is an uncommon congenital heart anomaly that is sporadically associated with pulmonary arterial hypertension in the adult population.
Alex Pizzini, Thomas Sonnweber, Renate Frank, Markus Theurl, Günter Weiss, Ivan Tancevski, Judith Löffler-Ragg   +6 more
doaj   +1 more source

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Journal of Cardiothoracic Surgery, 2021
Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease, which is mainly caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole itself, which eventually leads to right ...
Jianying Deng
doaj   +1 more source

CXCR4 Inhibition Ameliorates Severe Obliterative Pulmonary Hypertension and Accumulation of C-Kit+ Cells in Rats [PDF]

, 2014
Successful curative treatment of severe pulmonary arterial hypertension with luminal obliteration will require a thorough understanding of the mechanism underlying the development and progression of pulmonary vascular lesions.
Alhussini, Aysar A., Voelkel, N.F., Alhussaini, A.A., Donatas Kraskauskas, Kraskauskiene, V., Daniela Farkas, Aysar A. Alhussaini (526867), Carlyne D. Cool (526869), Kraskauskas, Donatas, Cool, Carlyne D., Donatas Kraskauskas (289543), Cool, C.D., Bogaard, Harm J., Farkas, Daniela, Farkas, D., Norbert F Voelkel, Drake, Jennifer, Carlyne D Cool, Laszlo Farkas (91352), Norbert F. Voelkel (177151), Kraskauskiene, Vita, Jennifer I Drake, Aysar A Alhussaini, Drake, J.I., Bogaard, H.J., Voelkel, Norbert F., Jennifer I. Drake (526866), Farkas, L., Vita Kraskauskiene, Harm J. Bogaard (289545), Kraskauskas, D., Harm J Bogaard, Daniela Farkas (334698), Vita Kraskauskiene (526868), Laszlo Farkas, Farkas, Laszlo   +35 more
core   +1 more source

Incident pulmonary arterial hypertension associated with Bosutinib

Pulmonary Circulation, 2020
Pulmonary arterial hypertension is associated with tyrosine kinase inhibitors used in the treatment of chronic myeloid leukemia. Dasatinib is a known cause of drug-induced pulmonary arterial hypertension.
Shaun Yo, John Thenganatt, Jeffrey Lipton, John Granton   +3 more
doaj   +1 more source

The role of the right ventricle in pulmonary arterial hypertension [PDF]

, 2011
Although changes in the pulmonary vasculature are the primary cause of pulmonary arterial hypertension (PAH), severity of symptoms and survival are strongly associated with right ventricular function, and right heart failure is the main cause of death in
A. Vonk Noordegraaf, Vonk Noordegraaf, A., N. Galiè, Galie, N.   +3 more
core   +3 more sources

Effect of Pomegranate Extract (Punica Granatum L) on Pulmonary Arterial Pressure in Sprague Dawley Rat with Pulmonary Arterial Hypertension [PDF]

, 2020
Congenital heart disease causes pulmonary arterial hypertension, heart failure, and early death. Pulmonary arterial hypertension causes pulmonary arterial wall remodeling, inflammation, deposition of extracellular matrix protein, collagen synthesis, and ...
Taufiq Hidayat, -, I Ketut Alit Utamayasa, -, Mahrus A. Rahman, -   +2 more
core   +1 more source