Results 11 to 20 of about 194,414 (305)

Application of [18F]FLT‐PET in pulmonary arterial hypertension: a clinical study in pulmonary arterial hypertension patients and unaffected bone morphogenetic protein receptor type 2 mutation carriers [PDF]

Pulmonary Circulation, 2021
Pulmonary arterial hypertension is a heterogeneous group of diseases characterized by vascular cell proliferation leading to pulmonary vascular remodelling and ultimately right heart failure. Previous data indicated that 3′‐deoxy‐3′‐[18F]‐fluorothymidine
Liza Botros, Samara M.A. Jansen, Ali Ashek, Onno A. Spruijt, Jelco Tramper, Anton Vonk Noordegraaf, Jurjan Aman, Hans Harms, Frances S. deMan, Marc C. Huisman, Lan Zhao, Harm J. Bogaard   +11 more
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Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
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Pulmonary arterial hypertension [PDF]

Orphanet Journal of Rare Diseases, 2013
Abstract Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point (California, USA) revised previous classifications.
Montani, David, Günther, Sven, Dorfmüller, Peter, Perros, Frédéric, Girerd, Barbara, Garcia, Gilles, Jaïs, Xavier, Savale, Laurent, Artaud-Macari, Elise, Price, Laura, Humbert, Marc, Simonneau, Gérald, Sitbon, Olivier   +12 more
openaire   +3 more sources

Effect of riociguat on pulmonary arterial compliance in the PATENT and CHEST studies

Pulmonary Circulation, 2020
Pulmonary arterial compliance is a measure of the pulsatile afterload of the right ventricle. Lower pulmonary arterial compliance is associated with reduced right ventricular function and worse prognosis in pulmonary hypertension. The effect of pulmonary
Thenappan Thenappan, Nadine Al-Naamani, Stefano Ghio, Hossein-Ardeschir Ghofrani, Paul M. Hassoun, Marc Pritzker, Adam Torbicki, Sylvia Nikkho, Dennis Busse, Ioana R. Preston   +9 more
doaj   +1 more source

Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension

Pulmonary Circulation, 2020
Platelet-derived growth factor is one of the major growth factors found in human and mammalian serum and tissues. Abnormal activation of platelet-derived growth factor signaling pathway through platelet-derived growth factor receptors may contribute to ...
Kang Wu, Haiyang Tang, Ruizhu Lin, Shane G. Carr, Ziyi Wang, Aleksandra Babicheva, Ramon J. Ayon, Pritesh P. Jain, Mingmei Xiong, Marisela Rodriguez, Shamin Rahimi, Francesca Balistrieri, Shayan Rahimi, Daniela Valdez-Jasso, Tatum S. Simonson, Ankit A. Desai, Joe G.N. Garcia, John Y.-J. Shyy, Patricia A. Thistlethwaite, Jian Wang, Ayako Makino, Jason X.-J. Yuan   +21 more
doaj   +1 more source

Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic

Pulmonary Circulation, 2020
The COVID-19 pandemic presents many unique challenges when caring for patients with pulmonary hypertension. The COVID-19 pandemic has altered routine standard of care practice and the acute management particularly for those patients with pulmonary ...
John J. Ryan, Lana Melendres-Groves, Roham T. Zamanian, Ronald J. Oudiz, Murali Chakinala, Erika B. Rosenzweig, Mardi Gomberg-Maitland   +6 more
doaj   +1 more source

Pulmonary artery denervation for pulmonary arterial hypertension

Trends in Cardiovascular Medicine, 2021
Pulmonary arterial hypertension remains a progressive, life-limiting disease despite optimal medical therapy. Pulmonary artery denervation has arisen as a novel intervention in the treatment of pulmonary arterial hypertension, and other forms of pulmonary hypertension, with the aim of reducing the sympathetic activity of the pulmonary circulation.
Constantine, A, Dimopoulos, K
openaire   +3 more sources

High geographic prevalence of pulmonary artery hypertension: associations with ethnicity, drug use, and altitude

Pulmonary Circulation, 2020
While estimates of pulmonary arterial hypertension incidence and prevalence commonly range from 1–3/million and 15–25/million, respectively, clinical experience at our institution suggested much higher rates.
Jason Dubroff, Lana Melendres, Yan Lin, Daniel Raley Beene, Loren Ketai   +4 more
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Clinical implications of partial anomalous pulmonary venous connection: a rare cause of severe pulmonary arterial hypertension

Pulmonary Circulation, 2020
Isolated partial anomalous pulmonary venous connection (PAPVC) is an uncommon congenital heart anomaly that is sporadically associated with pulmonary arterial hypertension in the adult population.
Alex Pizzini, Thomas Sonnweber, Renate Frank, Markus Theurl, Günter Weiss, Ivan Tancevski, Judith Löffler-Ragg   +6 more
doaj   +1 more source

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Journal of Cardiothoracic Surgery, 2021
Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease, which is mainly caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole itself, which eventually leads to right ...
Jianying Deng
doaj   +1 more source