Results 71 to 80 of about 194,414 (305)

Specific risk factors for heart-lung transplantation

JHLT Open
Background: Heart-lung transplantation (HLTx) has become increasingly rare, with fewer than 50 procedures performed annually worldwide. This decline reflects evolving indications, notably the predominance of Eisenmenger syndrome (ES) complicating ...
Justin Issard, Jérôme Le Pavec, Gaelle Dauriat, Estibaliz Valdeolmillos, Sébastien Hascoet, Jean Noel Andarelli, Sylvain Diop, Thibaut Genty, Laurent Savale, Olaf Mercier, Elie Fadel   +10 more
doaj   +1 more source

Echocardiography and Pulmonary Arterial Hypertension

Monaldi Archives for Chest Disease, 2016
Pulmonary Arterial Hypertension (PAH) is an heterogeneous condition brought on by a wide range of causes. It is characterized by structural changes in small pulmonary arteries, that produce a progressive increase in pulmonary artery pressure and pulmonary vascular resistance, ultimately leading to right ventricle failure and death.
Bossone Eduardo, Citro R, Ruggiero Alberto, Kuersten Bettina, Gregorio Giovanni, Blasi Francesco, Allegra Luigi   +6 more
openaire   +6 more sources

Right ventricular function in scleroderma-related pulmonary hypertension

, 2008
SSc-associated pulmonary arterial hypertension (PAH) has a poorer prognosis than that of other types of pulmonary hypertension. Recent echocardiographic and haemodynamic studies suggest that right ventriculer (RV) pump function and filling ...
A. Vonk Noordegraaf, Vonk Noordegraaf, Anton Vonk, Vonk Noordegraaf, A., Naeije, R., Naeije, Robert, R. Naeije   +5 more
core   +1 more source

Tadalafil in patients with chronic obstructive pulmonary disease:a randomised, double-blind, parallel-group, placebo-controlled trial [PDF]

, 2014
Background: Phosphodiesterase-5 (PDE5) inhibitors improve exercise capacity and quality of life in patients with idiopathic pulmonary arterial hypertension.
Lipworth, Brian J., Hopkinson, Pippa J, Struthers, Allan D., Goudie, Andrew R, Hopkinson, Pippa J., Lipworth, Brian J, Goudie, Andrew R., Wei, Li, Struthers, Allan D   +8 more
core   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

“Anagrelide-induced pulmonary arterial hypertension”: a rare case of drug-induced pulmonary arterial hypertension

Pulmonary Circulation, 2019
Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported.
Keiko Sumimoto, Yu Taniguchi, Yoichiro Matsuoka, Hiroyuki Onishi, Noriaki Emoto, Ken-ichi Hirata   +5 more
doaj   +1 more source

Adult congenital heart care in the COVID-19 era, and beyond: A call for actionKey Points

International Journal of Cardiology Congenital Heart Disease, 2020
While virus epidemics are nothing new to man, the scale, speed of global spread and immediacy of the COVID-19 pandemic have been truly unprecedented [1].
Michael A. Gatzoulis, Natali Chung, Paolo Ferrero, Massimo Chessa, George Giannakoulas, Aphrodite Tzifa, Gerhard P. Diller, Margarita Brida, Nada Al-Sakini   +8 more
doaj   +1 more source

Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology.

, 2013
Survival in patients with pulmonary arterial hypertension (PAH) is closely related to right ventricular (RV) function. Although pulmonary load is an important determinant of RV systolic function in PAH, there remains a significant variability in RV ...
Voelkel, N.F., Kawut, Steven M, Forfia, Paul R, Voelkel, Norbert F, Provencher, Steve, Oudiz, Ronald J, Haddad, F., Kawut, S.M., Newman, J., Kawut, Steven M., Naeije, R., Hassoun, P.M., Chin, Kelly M, Lumens, Joost, Forfia, Paul R., Newman, John, Voelkel, Norbert F., Forfia, P.R., Vonk-Noordegraaf, Anton, Lumens, Joost; id_orcid, Oudiz, Ronald J., Chin, K.M., Hassoun, Paul M, Torbicki, Adam, Oudiz, R.J., Hassoun, Paul M., Vonk-Noordegraaf, A., Torbicki, A., Chin, Kelly M., Provencher, S., Lumens, J., Haddad, François, Naeije, Robert   +32 more
core   +1 more source

Retinal Vessel Segmentation: A Comprehensive Review From Classical Methods to Deep Learning Advances (1982–2025)

Advanced Intelligent Systems, EarlyView.
Four decades of retinal vessel segmentation research (1982–2025) are synthesized, spanning classical image processing, machine learning, and deep learning paradigms. A meta‐analysis of 428 studies establishes a unified taxonomy and highlights performance trends, generalization capabilities, and clinical relevance.
Avinash Bansal, Jan Kubíček, Jana Bahrová, Alice Varyšová, Martin Augustýnek, Marek Penhaker, Juraj Timkovič   +6 more
wiley   +1 more source

Cardiac sympathetic dysfunction in pulmonary arterial hypertension: lesson from left-sided heart failure

Pulmonary Circulation, 2019
Sympathetic nervous system hyperactivity has a well-recognized role in the pathophysiology of heart failure with reduced left ventricular ejection fraction.
Valentina Mercurio, Teresa Pellegrino, Giorgio Bosso, Giacomo Campi, Paolo Parrella, Valentina Piscopo, Carlo G. Tocchetti, Paul M. Hassoun, Mario Petretta, Alberto Cuocolo, Domenico Bonaduce   +10 more
doaj   +1 more source