Results 81 to 90 of about 1,137,821 (328)

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

Surgery for pulmonary aspergillosis [PDF]

European Journal of Cardio-Thoracic Surgery, 1997
Surgery of pulmonary aspergillosis followed by higher incidence of post-operative complications. This was the purpose to evaluate our material.Between January 1983 and December 1995, the operation was carried out on a total of 84 patients for pulmonary aspergillosis.
Agócs L, Heiler Z, Attila Csekeo, Egerváry M   +3 more
openaire   +3 more sources

Challenges in optimizing tacrolimus therapy in patients treated with rifampin: A case series

British Journal of Clinical Pharmacology, EarlyView.
Tacrolimus is a cornerstone immunosuppressant in transplantation medicine with a narrow therapeutic window. Drug–drug interactions with strong CYP3A4 and P‐glycoprotein modulators, such as rifampin and azole antifungals, significantly alter tacrolimus exposure and complicate therapy. Two transplant cases illustrates the impact of rifampin on tacrolimus
Jeroen P. A. Houwen, Aurelia H. M. de Vries Schultink, Bas J. M. Peters, Dieuwertje Ruigrok, Rob H. J. Schönwetter, Esther V. Uijtendaal, Maaike A. Sikma   +6 more
wiley   +1 more source

Pulmonary Aspergillosis in Patients with Cystic Fibrosis in Russian Federation

Журнал инфектологии, 2018
The aim: to assess the incidence of various forms of pulmonary aspergillosis in patients with cystic fibrosis.Materials and methods. In 2014-2017 yy. in prospective study in  different regions of Russia were included 190 patients with cystic  fibrosis ...
Ya. I. Kozlova, Yu. V. Borzova, O. V. Shadrivova, I. E. Suslova, O. V. Aak, S. M. Ignat’eva, T. S. Bogomolova, V. A. Ponnaja, T. A. Stepanenko, A. V. Orlov, S. A. Krasovskiy, N. N. Klimko   +11 more
doaj   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Clinical, radiological, and microbiological profile of pulmonary aspergillosis in treated cases of pulmonary tuberculosis

Indian Journal of Allergy Asthma and Immunology, 2018
Context: Clinical studies about detailed spectrum of aspergillosis in treated tuberculosis (TB) patients are lacking. Hence, a study was undertaken at the Institute of Respiratory Disease, Jaipur, Rajasthan, India. Treated patients of pulmonary TB having
Shubhra Jain, Yogendra Singh Rathore, Vinod Joshi, Narendra Khippal   +3 more
doaj   +1 more source

Exhaled Volatile Organic Compounds for Identifying Patients With Chronic Pulmonary Aspergillosis

Frontiers in Medicine, 2021
Background: Diagnosing chronic pulmonary aspergillosis is a major challenge in clinical practice. The development and validation of a novel, sensitive and specific assay for diagnosing chronic pulmonary aspergillosis is urgently needed.Methods: From ...
Zheng-Tu Li, Pei-Ying Zeng, Zhao-Ming Chen, Wei-Jie Guan, Wei-Jie Guan, Tong Wang, Tong Wang, Ye Lin, Shao-Qiang Li, Zhi-Juan Zhang, Zhi-Juan Zhang, Zhi-Juan Zhang, Yang-Qing Zhan, Ming-Die Wang, Guo-Bin Tan, Guo-Bin Tan, Guo-Bin Tan, Xue Li, Xue Li, Feng Ye   +19 more
doaj   +1 more source

A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis [PDF]

, 2016
published_or_final_versio
Chan, JFW, Chan, SM, Cheng, VCC, Hung, FNI, Lau, SKP, Leung, SS, Pang, CM, So, SY, To, KKW, Wong, SC, Woo, PCY, Xiao, C, Yuen, KY   +12 more
core   +1 more source

Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report

Journal of Fungi, 2020
COVID-19-associated pulmonary aspergillosis (CAPA) is a recently described disease entity affecting patients with severe pulmonary abnormalities treated in intensive care units. Delays in diagnosis contribute to a delayed start of antifungal therapy.
Eelco F. J. Meijer, A. Dofferhoff, O. Hoiting, Jochem B. Buil, J. Meis   +4 more
semanticscholar   +1 more source

Nebulised surface-active hybrid nanoparticles of voriconazole for pulmonary Aspergillosis demonstrate clathrin-mediated cellular uptake, improved antifungal efficacy and lung retention

Journal of Nanobiotechnology, 2021
Background Incidence of pulmonary aspergillosis is rising worldwide, owing to an increased population of immunocompromised patients. Notable potential of the pulmonary route has been witnessed in antifungal delivery due to distinct advantages of direct ...
Ranjot Kaur, S. Dennison, A. J. Burrow, S. Rudramurthy, R. Swami, Varun Gorki, O. Katare, Anupama Kaushik, Bhupinder Singh, K. Singh   +9 more
semanticscholar   +1 more source