A multicore parallel algorithm for multiscale modelling of an entire human blood circulation network [PDF]
The presented multi-scale, closed-loop blood circulation model includes arterial, venous, and portal venous systems, heart-pulmonary circulation, and micro-circulation in capillaries. One-dimensional models simulate large blood vessel flow, whereas zerodimensional models are used for simulating blood flow in vascular subsystems corresponding to ...
arxiv
THE EFFECT OF EPINEPHRINE ON THE PULMONARY CIRCULATION IN MAN 1 [PDF]
A.Calhoun Witham, J. W. Fleming
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Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang+6 more
wiley +1 more source
EFFECTS OF ACUTE ANOXIA ON THE CIRCULATION AND RESPIRATION IN PATIENTS WITH CHRONIC PULMONARY DISEASE STUDIED DURING THE “STEADY STATE” 1 [PDF]
A. P. Fishman+3 more
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This study presents decursin, a traditional Chinese medicine monomer, that inhibits lipid accumulation and inflammation in atherosclerosis through PKCδ interaction. A novel targeted delivery system (ALD@EM) is developed to overcome decursin's short half‐life, combining antibody‐mediated targeting, LDL‐facilitated chemotaxis, and enhanced macrophage ...
Hui Chen+13 more
wiley +1 more source
TRANSCAPILLARY MIGRATION OF HEAVY WATER AND THIOCYANATE ION IN THE PULMONARY CIRCULATION OF NORMAL SUBJECTS AND PATIENTS WITH CONGESTIVE HEART FAILURE 123 [PDF]
Lawrence S. Lilienfield+3 more
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A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang+4 more
wiley +1 more source
Pulmonary hypertension (PH) is featured by pulmonary vascular and cardiac remodeling. Rehabilitation exercise can improve patients’ quality of life. We previously pinpointed a potential glutamine metabolism dysfunction in PH. Hence, we aim to investigate
Shang Wang+8 more
doaj
STUDIES OF THE PULMONARY CIRCULATION IN MAN AT REST. NORMAL VARIATIONS AND THE INTERRELATIONS BETWEEN INCREASED PULMONARY BLOOD FLOW, ELEVATED PULMONARY ARTERIAL PRESSURE, AND HIGH PULMONARY “CAPILLARY” PRESSURES 1 [PDF]
L Dexter+6 more
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Recent Advances in mRNA Delivery Systems for Cancer Therapy
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang+9 more
wiley +1 more source