Results 131 to 140 of about 29,596 (295)

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

PULMONARY DIFFUSING CAPACITY, PULMONARY MEMBRANE DIFFUSING CAPACITY AND PULMONARY CAPILLARY BLOOD VOLUME AT REST AND DURING EXERCISE

, 1976
Keiji Yamaji, Mitsumasa Miyashita
openalex   +2 more sources

Diffusing Lung Capacity Reveals Phenotypical Complexity in Pulmonary Hypertension [PDF]

, 2015
Navitha Ramesh, David Nesheim, Michael Lau, Jason Filopei, Michael Bergman, Sarun Thomas, Roxana Sulica, Albert Miller   +7 more
openalex   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

A STUDY ON THE PULMONARY FUNCTIONS AND THE PULMONARY CIRCULATION IN CARDIO-PULMONARY DISEASES : (I) Pulmonary Diffusing Capacity in Cardio-Pulmonary Diseases

, 1971
Katsutomo Yuba
openalex   +2 more sources

LncDARS‐AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis

Advanced Science, EarlyView.
This study identifies LncDARS‐AS1 as a novel oncogenic regulator that stabilizes ATP1A1 and enhances Na⁺/K⁺ ATPase activity, promoting osteosarcoma metastasis. Targeting the LncDARS‐AS1/ATP1A1/NKA axis, including pharmacological inhibition with digoxin, offers promising opportunities for the development of new therapeutic strategies against ...
Mingxian Xu, Jiatian Wei, Xiaoyu Feng, Qinkai Zhang, Jian Chen, Xinyue Wang, Xiudan Zhan, Bing Lu, Weitang Guo, Mingzhe Cheng, Renxuan Huang, Shao Xu, Changye Zou   +12 more
wiley   +1 more source

A NEW TREATMENT OF THE PULMONARY DIFFUSING CAPACITY BY THE SINGLE BREATH METHOD

, 1971
Shuichi Takahashi
openalex   +2 more sources

Mucociliary Clearance Inspired Nanozyme‐centric Hydrogel Composites for Integrated Bacterial Detection

Advanced Science, EarlyView.
Inspired by human pulmonary cilia and their mucus defend against bacteria, nanozyme‐centric hydrogel networks have been assembled into nanowires, combining the rapid penetration capability of the nanowire arrays with the adhesion and detection functions of the nanozyme‐centric hydrogel networks.
Zhaoling Tan, Xuejiao Wang, Zhaoyue Wang, Jieke Jiang, Xi Yao   +4 more
wiley   +1 more source

Impact of Hemoglobin and Carboxyhemoglobin Adjustment on the Interpretation of Pulmonary Diffusing Capacity in a General Population [PDF]

, 2017
Jeffrey M Haynes, Gregg L Ruppel, David A. Kaminsky   +2 more
openalex   +1 more source