Results 61 to 70 of about 30,235 (338)

New Spirometry Indices for Detecting Mild Airflow Obstruction. [PDF]

, 2018
The diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstration of airflow obstruction. Traditional spirometric indices miss a number of subjects with respiratory symptoms or structural lung disease on imaging.
Barjaktarevic, Igor, Bhakta, Nirav R, Bhatt, Surya P, Bodduluri, Sandeep, Castaldi, Peter J, Cooper, Christopher B, Dransfield, Mark T, Eberlein, Michael, Han, MeiLan K, Kim, Young-Il, Nakhmani, Arie, Sciurba, Frank C, Wilson, Carla G, Woodruff, Prescott G   +13 more
core   +2 more sources

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Loss of alveolar membrane diffusing capacity and pulmonary capillary blood volume in pulmonary arterial hypertension

Respiratory Research, 2013
Background Reduced gas transfer in patients with pulmonary arterial hypertension (PAH) is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary blood volume available for gas ...
Farha Samar, Laskowski Daniel, George Deepa, Park Margaret M, Tang WH Wilson, Dweik Raed A, Erzurum Serpil C   +6 more
doaj   +1 more source

Modeling of Red Blood Cells in Capillary Flow Using Fluid–Structure Interaction and Gas Diffusion

Cells, 2022
Red blood cell (RBC) distribution, RBC shape, and flow rate have all been shown to have an effect on the pulmonary diffusing capacity. Through this study, a gas diffusion model and the immersed finite element method were used to simulate the gas ...
Ling An, Fenglong Ji, Yueming Yin, Yi Liu, Chichun Zhou   +4 more
doaj   +1 more source

Extracorporeal Catalytic Hemoperfusion Therapy for Refractory Septic Shock Using Ceria Nanoparticle‐Embedded Porous Microbeads

Advanced Functional Materials, EarlyView.
This study introduces an extracorporeal hemoperfusion system incorporating porous microbeads embedded with autocatalytic ceria nanoparticles (CeNPs) for targeted reactive oxygen species (ROS) scavenging in septic shock. The blood‐compatible hemoperfusion cartridge demonstrated significant improvements in survival, hemodynamic stability, and organ ...
Pilseon Im, Han‐Gil Jeong, Donghee Kim, Jimin Song, Ngoc Man Phan, Eun‐seo Choi, Young‐Min Kim, Seo‐Hyeon Jeong, Jooho Park, Inwon Park, Jaeyun Kim   +10 more
wiley   +1 more source

Relationship between diffusion capacity and small airway abnormality in COPDGene. [PDF]

, 2019
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD,
Casaburi, Richard, Criner, Rachel N, Curtis, Jeffrey L, Galbán, Craig J, Han, Mei Lan K, Hatt, Charles R, Kazerooni, Ella A, Labaki, Wassim W, Lynch, David A, MacIntyre, Neil R, Make, Barry J, Martinez, Fernando J, McCormack, Meredith C   +12 more
core   +1 more source

Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients [PDF]

, 2009
BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline.
A Papi, AK Sullivan, AT Society, B Barcelo, B Meshi, BH Nelson, C Fletcher, CS Robbins, CS Robbins, DL Mueller, DW Perng, F Mor, G Rohde, GJ de Bree, J Chang, J Chang, JL Hankinson, L Lintomen, L Taraseviciene-Stewart, L Van Parijs, L Van Parijs, M Decramer, M Miller, M Saetta, M Saetta, MD Roth, N Tzanakis, NR Anthonisen, P Glader, PC Doherty, PD Ponath, PD Ponath, PJ Barnes, PT King, RO Crapo, RW Vandivier, S Chakrabarti, S Hodge, S Hodge, S Hodge, S Wei, T Seemungal, TC O'Shaughnessy, V Bocchino   +43 more
core   +4 more sources

Biodegradable, Humidity‐Insensitive Mask‐Integrated E‐Nose for Sustainable and Non‐Invasive Continuous Breath Analysis

Advanced Functional Materials, EarlyView.
This study introduces a paper‐based biodegradable, humidity‐insensitive e‐nose for real‐time breath analysis, addressing challenges in existing technologies such as humidity interference, high costs, and environmental impact. Featuring hydrophobic polymer coatings, these sensors reliably detect VOCs even in high‐moisture environments.
Indrajit Mondal, Adan Zoabi, Hossam Haick   +2 more
wiley   +1 more source

Pulmonary 99mTc-HMDP uptake correlates with restrictive ventilatory defects and abnormal lung reactance in transthyretin cardiac amyloidosis patients

Respiratory Research, 2022
Background Pulmonary involvement in individuals with transthyretin cardiac amyloidosis is unclear. The aim of this study was to quantify 99mTc-hydroxy methylene diphosphonate (HMDP) lung retention in hereditary transthyretin (ATTRv) cardiac amyloidosis ...
Astrid Monfort, Alexia Rivas, Rishika Banydeen, Jocelyn Inamo, Karim Farid, Remi Neviere   +5 more
doaj   +1 more source

Hierarchical stratification of the factors related to exertional dyspnoea and exercise intolerance in male COPD patients

Annals of Medicine, 2022
Background The order and extent of interactions across the factors affecting exertional dyspnoea (ED) and exercise intolerance (EI) in patients with chronic obstructive pulmonary disease (COPD) are not clear.
Ming-Lung Chuang
doaj   +1 more source