Results 241 to 250 of about 1,719,335 (360)
Screening for chronic pulmonary disease--the Alabama experience.
K. W. Grimley+2 more
openalex +2 more sources
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo+20 more
wiley +1 more source
Paradigm Shift in the Treatment of Chronic Obstructive Pulmonary Disease Improves Patient Outcomes. [PDF]
Huang YJ+6 more
europepmc +1 more source
Alterations in Regional Pulmonary Blood Flow in Mitral Valve Disease Studied by Radioisotope Scanning [PDF]
William F. Friedman, Eugene Braunwald
openalex +1 more source
Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao+8 more
wiley +1 more source
Association of Life's Essential 8 with the prevalence and mortality of chronic obstructive pulmonary disease. [PDF]
Shi Y, Huang D, Liu Y, Huang N.
europepmc +1 more source
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu+18 more
wiley +1 more source
Metabolomic Plasma Profile of Chronic Obstructive Pulmonary Disease Patients. [PDF]
Casadevall C+20 more
europepmc +1 more source
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin+11 more
wiley +1 more source
Lipid metabolism reprogramming in chronic obstructive pulmonary disease. [PDF]
Liang Q, Wang Y, Li Z.
europepmc +1 more source