Results 181 to 190 of about 1,859,821 (399)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

Advanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu, Yunyuan Yu, Guangrong Yin, Huiqun Hu, Shishuo Li, Yuting Tang, Yimin Liu, Maoyuan Li, Liang liang Wang, Chao Xu, Gongyin Zhao, Baojun Zhou, Yuji Wang   +12 more
wiley   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

P16‐80: Differential source of early phase discontinuation between pirfenidone and nintedanib in patients with idiopathic pulmonary fibrosis [PDF]

, 2021

openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Pyroptosis-related signatures predict immune characteristics and prognosis in IPF

Heliyon
The purpose of this work was to use integrated bioinformatics analysis to screen for pyroptosis-related genes (PRGs) and possible immunological phenotypes linked to the development and course of IPF.
Yijun He, Tingting Yao, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiangyu Zhang, Xin Lv, Yuanyuan Han, Xiaoyun Cheng, Mengyu Li, Mao Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng   +13 more
doaj   +1 more source

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study

, 2017
Toby M. Maher, Eunice Oballa, Juliet K. Simpson, Joanne Porte, Anthony Habgood, William A. Fahy, Aiden Flynn, Philip L. Molyneaux, Rebecca Braybrooke, Hrushikesh Divyateja, Helen Parfrey, Doris M. Rassl, Anne‐Marie Russell, Gauri Saini, Elisabetta Renzoni, Anne-Marie R. Duggan, Richard Hubbard, Athol U. Wells, Pauline T. Lukey, Richard P. Marshall, Gísli Jenkins   +20 more
openalex   +2 more sources

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Advanced Science
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The
Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Ruoyu Duan, Zhihua Ji, Xiaoyue Pan, Yanlin Zhou, Guoying Yu, Lan Wang   +9 more
doaj   +1 more source

TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

iScience
Summary: The ubiquitin-proteasome system (UPS) critically regulates protein stability and function. E3 ligase dysregulation plays a crucial role in idiopathic pulmonary fibrosis (IPF). TRIM36, a RING-finger E3 ligase with emerging tumor-suppressive roles
Yajun Li, Yuexia Yang, Yingjie Wang, Feifan Shi, Yue Zhang, Hongzhi Wen, Xin Pan, Cong Xia, Zhongzheng Li, Kaisa Cui, Guojun Zhao, Huibing Liu, Qiwen Wang, Lan Wang, Guoying Yu   +14 more
doaj   +1 more source

High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis [PDF]

, 2008
Tomoyuki Kakugawa, Shin‐ichi Yokota, Hiroshi Mukae, Hiroshi Kubota, Noriho Sakamoto, Syunji Mizunoe, Yasuhiro Matsuoka, Jun‐ichi Kadota, Nobuhiro Fujii, Kazuhiro Nagata, Shigeru Kohno   +10 more
openalex   +1 more source