Results 41 to 50 of about 51,249 (164)

COVID‐19 critical illness pathophysiology driven by diffuse pulmonary thrombi and pulmonary endothelial dysfunction responsive to thrombolysis

open access: yesClinical and Translational Medicine, 2020
Patients with severe COVID‐19 disease have been characterized as having the acute respiratory distress syndrome (ARDS). Critically ill COVID‐19 patients have relatively well‐preserved lung mechanics despite severe gas exchange abnormalities, a feature ...
Hooman D. Poor   +9 more
doaj   +1 more source

Novel Use of a Bronchial Blocker in a Challenging Case of Congenital Diaphragmatic Hernia—A Case Report

open access: yesChildren, 2021
The diagnosis of congenital diaphragmatic hernia (CDH) is associated with significant morbidity and mortality. Survival of neonates with CDH has improved recently, although the clinical course is complicated by sequelae of hypoplastic pulmonary ...
Deepika Sankaran   +4 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

open access: yesAdvanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa   +3 more
wiley   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

open access: yesAdvanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade   +19 more
wiley   +1 more source

Changes in lung mechanics and ventilation-perfusion match: comparison of pulmonary air- and thromboembolism in rats

open access: yesBMC Pulmonary Medicine
Background Pulmonary air embolism (AE) and thromboembolism lead to severe ventilation-perfusion defects. The spatial distribution of pulmonary perfusion dysfunctions differs substantially in the two pulmonary embolism pathologies, and the effects on ...
József Tolnai   +7 more
doaj   +1 more source

Abnormal Exercise Gas Exchange Before Pulmonary Emboli Diagnosis

open access: yesMayo Clinic Proceedings: Innovations, Quality & Outcomes
A 20-year-old male underwent diagnostic testing due to unexplained shortness of breath and chest discomfort. He had no previous medical problems and was not taking any medications.
Timothy Edwards, MS   +2 more
doaj   +1 more source

A Multivariable Index for Grading Exercise Gas Exchange Severity in Patients with Pulmonary Arterial Hypertension and Heart Failure

open access: yesPulmonary Medicine, 2012
Patients with pulmonary arterial hypertension (PAH) and heart failure (HF) display many abnormalities in respiratory gas exchange. These abnormalities are accentuated with exercise and track with disease severity.
Chul-Ho Kim   +3 more
doaj   +1 more source

PATHOLOGIC PHYSIOLOGY OF EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

open access: yesВестник анестезиологии и реаниматологии, 2019
The lecture describes the mechanisms of deterioration of respiratory exchange during exacerbation of chronic obstructive pulmonary disease (COPD). It has been demonstrated that the rapid diagnosis and treatment of exacerbations is an important part of ...
S. N. Avdeev
doaj   +1 more source

Hyperpolarized Xe MR imaging of alveolar gas uptake in humans. [PDF]

open access: yesPLoS ONE, 2010
One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and ...
Zackary I Cleveland   +10 more
doaj   +1 more source

Pulmonary gas exchange in elderly subjects [PDF]

open access: yesEuropean Respiratory Journal, 1996
Although important alterations in structure and function develop with age, the hypothesis that the lungs are capable of maintaining adequate gas exchange for the maximum human life span is generally accepted. This hypothesis was examined by measuring arterial oxygen and carbon dioxide tension (Pa,O2 and Pa,CO2) alveolo-arterial differences in oxygen ...
H, Guénard, R, Marthan
openaire   +2 more sources

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