Results 91 to 100 of about 827,342 (360)

The potential clinical implications of slow vital capacity in patients with idiopathic pulmonary fibrosis

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a highly variable clinical course. Forced vital capacity (FVC) is widely used as a marker of disease severity and progression, yet its variability and dependence on ...
Ho Cheol Kim, Sydney Guthrie, Christopher S. King, Shazia Khan, Christopher A. Thomas, Vikramjit Khangoora, Steven D. Nathan   +6 more
doaj   +1 more source

A summary of second systemic pulmonary shunt for congenital heart disease with pulmonary hypoxemia

Journal of Cardiothoracic Surgery, 2020
Background There has been an increasing number of children with congenital heart disease that undergo primary or second systemic-pulmonary shunt, while there are few reports on the second systemic-pulmonary shunt.
Xue-Yong Yang, Xiao-Yong Jing, Zhe Chen, Lun Li, Xiang-Ming Fan, Jun-Wu Su   +5 more
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Beta-blocker under-use in COPD patients [PDF]

, 2017
Background: Cardiovascular (CVS) comorbidities are common in COPD and contribute significantly to morbidity and mortality, especially following acute exacerbations of COPD (AECOPD).
Lavender, Melanie, Lim, Kuan Pin, Loughrey, Sarah, Musk, Michael, Wrobel, Jeremy P   +4 more
core   +2 more sources

Lung Function in Young Adults and Risk of Cardiovascular Events Over 29 Years: The CARDIA Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Diminished peak lung function in young adulthood is a risk factor for future chronic obstructive pulmonary disease. The association between lung disease and cardiovascular disease later in life is well documented.
Michael J. Cuttica, Laura A. Colangelo, Mark T. Dransfield, Surya P. Bhatt, Jamal S. Rana, David R. Jacobs, Bharat Thyagarajan, Stephen Sidney, Cora E. Lewis, Kiang Liu, Donald Lloyd‐Jones, George Washko, Ravi Kalhan   +12 more
doaj   +1 more source

Pulmonary Delivery of siRNA Anti‐TNFα‐loaded Lipid Nanoparticles for Rapid Recovery in Murine Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
In a murine model of acute lung injury, pulmonary administration of lipid nanoparticles carrying TNFα siRNA enables targeted delivery to immune cells. The study emphasises the importance of optimizing LNP distribution and delivery timing to improve therapeutic outcomes and develop emergency therapies for lung hyperinflammation.
Qinglin Wang, Jihana Achour, Laila Emam, Younes Louaguenouni, Catherine Cailleau, Françoise Mercier‐Nomé, Séverine Domenichini, Claudine Delomenie, Sezen Gul, Juliette Vergnaud, Nicolas Tsapis, Arnaud Mansart, Djillali Annane, Francois Fay, Elias Fattal   +14 more
wiley   +1 more source

The effect of heart disease on pulmonary function [PDF]

Postgraduate Medical Journal, 1976
Summary In pulmonary congestion dyspnoea is due not only to an increase in elastic but also in viscous work. Increased airway resistance can be reduced in most of these cases by inhalation of adrenergic or anti-cholinergic agents.
openaire   +3 more sources

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

Adverse reactions of amiodarone [PDF]

, 2019
Adverse drug reaction is defined by the World Health Organization as any response to a drug that is noxious and unintended and occurs at a dose normally used in man.
Calvosa, Leonardo, Ciacciarelli, Marco, Colunga Biancatelli, Ruben Ml, Congedo, Viviana, Iuliano, Luigi, Polidoro, Alessandro   +5 more
core   +1 more source

Karma of Cardiovascular Disease Risk Factors for Prevention and Management of Major Cardiovascular Events in the Context of Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Frontiers in Cardiovascular Medicine, 2019
There is compelling epidemiological evidence that airway exposure to cigarette smoke, air pollution particles, as well as bacterial and viral pathogens is strongly related to acute ischemic events.
Liliana Crisan, Nathan Wong, Don D. Sin, Hwa Mu Lee, Hwa Mu Lee   +4 more
doaj   +1 more source