Results 91 to 100 of about 789,285 (380)
Advanced Healthcare Materials, EarlyView.Efflux‐mediated resistance compromises antibiotic efficacy, yet rapid detection remains elusive. This study presents a novel phenazinium‐based diagnostic molecule for quantifying bacterial efflux levels in Gram‐positive pathogens. The optimized compound enables precise, real‐time efflux assessment using fluorescence and colorimetric techniques ...
Mrunal Patil +15 more
wiley +1 more source
AGING MEDICINE, Volume 5, Issue 4, Page 257-263, December 2022., 2022 The main finding in our study is that Clinical Frailty Scale‐defined frailty status was predictive of 1‐year post‐interventional mortality after left ventricular assist device implantation. Abstract Objectives Heart failure impacts patients’ functional capabilities, ultimately leading to frailty.
Temitope Ajibawo +3 more
wiley +1 more source
Interventional Cardiology: Reviews, Research, Resources, 2021 The use of exercise right heart catheterisation for the assessment of cardiovascular diseases has regained attention recently. Understanding physiologic haemodynamic exercise responses is key for the identification of abnormal haemodynamic patterns ...
Felipe H Valle +5 more
doaj +1 more source
Impact of ischemic and valvular heart disease on atrial excitation [PDF]
, 2018 Background--The influence of underlying heart disease or presence of atrial fibrillation (AF) on atrial excitation during sinus rhythm (SR) is unknown. We investigated atrial activation patterns and total activation times of the entire atrial epicardial ...
Bekkers, J.A. (Jos) +9 more
core +1 more source
Group sequential designs for negative binomial outcomes [PDF]
Statistical Methods in Medical Research, 2018,
https://journals.sagepub.com/doi/abs/10.1177/0962280218773115, 2017 Count data and recurrent events in clinical trials, such as the number of lesions in magnetic resonance imaging in multiple sclerosis, the number of relapses in multiple sclerosis, the number of hospitalizations in heart failure, and the number of exacerbations in asthma or in chronic obstructive pulmonary disease (COPD) are often modeled by negative ...
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The Fontan circulation is a successful operative strategy for abolishing cyanosis and chronic volume overload in patients with congenital heart disease with single ventricle physiology. “Fontan failure” is a major cause of poor quality of life
Andrew Constantine +14 more
doaj +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 81-90, January 2023., 2023 XELOXIRI neoadjuvant chemotherapy appears to be feasible and efficacious for patients with LARC. Although neoadjuvant XELOXIRI alone did not yield our expected pCR rate, the local recurrence rate, 3‐year DFS and measures of safety met current standards.
Chu Matsuda +16 more
wiley +1 more source
Clinical Features and Multimodality Diagnostic Tools of Pulmonary Hypertension [PDF]
Pulmonary hypertension (PH) is characterized by an increase in mean pulmonary artery pressure (mPAP) above normal, which is > 20 mmHg and an increase in pulmonary vascular resistance (pulmonary vascular resistance / PVR) above normal, in resting ...
Galuh, Lukitasari Ayu +3 more
core +2 more sources