Results 221 to 230 of about 8,356,254 (304)

A Bioengineered Mitochondrial Respiration‐Mimetic Copper‐Based Metal‐Organic Framework Reprogramming Oxidative Phosphorylation to Enhance Tumor Cuproptosis

Advanced Science, EarlyView.
A bioengineered mitochondrial respiration‐mimetic nanoplatform (TC@OMG) renews tumor mitochondrial metabolism to enhance cuproptosis. TC@OMG integrates a copper‐based metal‐organic framework co‐loaded with glucose oxidase and a lactate dehydrogenase inhibitor, and is cloaked with a hybrid membrane derived from tumor cells and plant thylakoids, enabling
Liyang Zhou, Hongpei Deng, Tingli Zheng, Huan Min, Qiwei Tian, Huimin Lin, Jing Ruan, Xianqun Fan   +7 more
wiley   +1 more source

LFA‐1‐Engineered Extracellular Vesicles Deliver CD59 to Protect Endothelial Integrity in Acute Lung Injury

Advanced Science, EarlyView.
LFA‐1‐engineered extracellular vesicles preferentially target pulmonary endothelium and deliver CD59, thereby inhibiting membrane attack complex formation, preserving vascular integrity, and attenuating acute lung injury. This strategy reveals a targeted approach for protecting the pulmonary vasculature from complement‐mediated damage.
Yin Zhu, Shravani Etrouth, Payaningal R. Somanath, S. Priya Narayanan, Yutao Liu, Xiaoyun Wang, Duo Zhang   +6 more
wiley   +1 more source

Cardiovascular complications in idiopathic pulmonary fibrosis and the emerging concept of the heart-lung fibrotic axis: a narrative review. [PDF]

Front Med (Lausanne)
Graczyk P, Keller D, Kuźnar-Kamińska B.   +2 more
europepmc   +1 more source

Spray‐Dried mRNA‐LNP Powder Enabling Multi‐Route Delivery With 3‐Year Refrigerated Stability

Advanced Science, EarlyView.
Spray‐dried mRNA‐LNP powder with trehalose matrix enables reconstitution for parenteral delivery or direct administration via pulmonary and sublingual routes, maintaining protein expression comparable to liquid controls. The thermostable powder preserves colloidal stability, mRNA integrity, and biological activity for over 3 years at 2°C–8°C, while ...
Ashish Sarode, Priyal Patel, Frank DeRosa, Shrirang Karve, Regis Gervier   +4 more
wiley   +1 more source

Association Between Cardiovascular Disease and Cataracts: Protocol for a Systematic Review and Meta-Analysis. [PDF]

JMIR Res Protoc
Yap JF, Heng PP, Wan Mohamad Darani WNS, Mat Rifin H, Muhamad NA, Pong MY, Mohd Yusoff MF.   +6 more
europepmc   +1 more source

Association Between Preoperative Steroid Use and Short‐Term Outcomes Following Pancreaticoduodenectomy: A Nationwide Analysis Using the National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Pancreaticoduodenectomy (PD) carries a high risk of postoperative complications. Although steroids are widely prescribed for various chronic diseases, the specific impact after PD remains unclear. This study evaluated the association between preoperative chronic steroid use and short‐term outcomes following PD.
Yoshito Tomimaru, Hideki Endo, Hiroyuki Yamamoto, Teruhide Ishigame, Hideki Ueno, Ken Shirabe, Hidetoshi Eguchi   +6 more
wiley   +1 more source

Minimally Invasive Versus Open Total and Distal Gastrectomy After Chemotherapy for Gastric Cancer: A Nationwide Observational Study

Annals of Gastroenterological Surgery, EarlyView.
This nationwide observational study used data from the National Clinical Database. Patients who underwent total or distal gastrectomy for gastric cancer after chemotherapy between January 2014 and December 2022 were included. Minimally invasive surgery was associated with lower incidences of overall postoperative complications of Clavien–Dindo grade ...
Nobuaki Hoshino, Shinya Hirakawa, Shiogeo Hisamori, Hisateru Tachimori, Yusuke Fujii, Koshi Kumagai, Hideki Ueno, Ken Shirabe, Kazutaka Obama   +8 more
wiley   +1 more source

Management of Non-cardiac Surgery in an Elderly Patient with Uncorrected Double Inlet Left Ventricle: Utility of the Pulse Contour Analysis-Based Cardiac Output Monitor. [PDF]

Ann Card Anaesth
Honda J, Yamazaki Y, Hasegawa T, Noji Y, Inoue S.   +4 more
europepmc   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Trends in circulatory system disease hospitalizations in England and Wales: A 21-year secular-trend analysis. [PDF]

Medicine (Baltimore)
Alomari E, Naser AY.
europepmc   +1 more source