Results 31 to 40 of about 8,356,254 (304)

High-risk pregnancy in a patient with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) with temporary shunt inversion and deoxygenation

Pulmonary Circulation, 2019
Atrial septal defect (ASD) is one of the most frequent congenital heart diseases (CHD). Up to 10% of adults with an ASD develop pulmonary arterial hypertension (PAH, PAH-CHD) in their lifetime.
Christopher Hohmann, Daniel Dumitrescu, Felix Gerhardt, Tilmann Kramer, Stephan Rosenkranz, Michael Huntgeburth   +5 more
doaj   +1 more source

Pilot study of losartan for pulmonary hypertension in chronic obstructive pulmonary disease. [PDF]

, 2005
BACKGROUND: Morbidity in COPD results from a combination of factors including hypoxia-induced pulmonary hypertension, in part due to pulmonary vascular remodelling. Animal studies suggest a role of angiotensin II and acute studies in man concur.
Shakur, B Haleema, Paul J Robinson, Morrell, Nicholas W, Peter G Phillips, Shakur B Haleema, Matthew A Higham, B Haleema Shakur, Robinson Paul J, Nicholas W Morrell, Ray J Beddoes, Robinson, Paul J, Beddoes, Ray J, Beddoes Ray J, Higham, Matthew A, Phillips Peter G, Phillips, Peter G, Higham Matthew A, Morrell Nicholas W   +17 more
core   +2 more sources

Adult congenital heart disease: Past, present, future

International Journal of Cardiology Congenital Heart Disease, 2020
The diagnosis and management of congenital heart disease (CHD), the most common inborn defect, has been a tremendous success story of modern medicine. In the 1950s survival of children born with CHD was only approximately 15%, whereas nowadays more than ...
Margarita Brida, Michael A. Gatzoulis
doaj   +1 more source

Predictors of outcome in adults with double outlet right ventricle

Open Heart
Background Double outlet right ventricle (DORV) encompasses a range of congenital heart defects. Although survival to adulthood has improved, late risks, particularly life-threatening arrhythmias and sudden cardiac death (SCD) persist.Objectives We ...
Wei Li, Konstantinos Dimopoulos, Aleksander Kempny, Sarah Bowater, Ee Ling Heng, Timothy J Jones, Paul F Clift, Lucy Hudsmith, Andreas Hoschtitzky, Saadiq Moledina, Natasha Khan, Sara Thorne, Sonya Babu-Narayan, Sayqa Arif, Sarah Ghonim, Michael Gatzoulis, Andrew Constantine, Phil Botha, Christopher Bond, Nada Al-Sakini, Madiha Iqbal, Omar Mubarak, Seshika D Ratwatte   +22 more
doaj   +1 more source

Cor pulmonale in canine patients

Ciencia Veterinaria, 2020
When we talk about cor pulmonale or pulmonary heart disease we refer to a heart that has been disrupted its structure and, therefore, its function as a result of chronic pulmonary disease.
Roberto Andrés Sosa, Antonela Soledad Mancuso, Roberto Edgardo Sosa   +2 more
doaj   +1 more source

Application of Artificial Intelligence-Based Auxiliary Diagnosis in Congenital Heart Disease Screening

Anatolian Journal of Cardiology, 2023
Background: To evaluate the application value of artificial intelligence-based auxiliary diagnosis for congenital heart disease. Methods: From May 2017 to December 2019, 1892 cases of congenital heart disease heart sounds were collected for learning ...
Hongbo Yang, Jiahua Pan, Weilian Wang, Tao Guo, Tengyuan Ma   +4 more
doaj   +1 more source

Targeted therapy with phosphodiesterase 5 inhibitors in patients with pulmonary hypertension due to heart failure and elevated pulmonary vascular resistance: a systematic review

Pulmonary Circulation, 2020
Pulmonary Hypertension due to left heart disease is the most common type of Pulmonary Hypertension. Morbidity and mortality significantly increase once Pulmonary Hypertension is present.
Galo M. Sanchez Palacios, Cindy Schmidt, Tammy Wichman   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Isolated right pulmonary artery discontinuity [PDF]

, 2000
Unilateral “absence” of the pulmonary artery is an uncommon malformation frequently associated with congenital heart disease. In fact, the pulmonary artery is typically discontinuous from the main pulmonary artery, not absent.
Vincent, J.A., Epstein, M.L., Turner, Daniel   +2 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source