Results 31 to 40 of about 1,820,387 (299)

Adult congenital heart disease: Past, present, future

International Journal of Cardiology Congenital Heart Disease, 2020
The diagnosis and management of congenital heart disease (CHD), the most common inborn defect, has been a tremendous success story of modern medicine. In the 1950s survival of children born with CHD was only approximately 15%, whereas nowadays more than ...
Margarita Brida, Michael A. Gatzoulis
doaj   +1 more source

Pulmonary hypertension associated with left heart disease

European Respiratory Journal
Left heart disease (LHD) is the most common cause of pulmonary hypertension (PH), which may be classified further as isolated post-capillary (ipcPH) or combined post- and pre-capillary PH (cpcPH).
B. A. Maron, G. Bortman, Teresa De Marco, J. Huston, Irene M. Lang, Stephan Rosenkranz, J. Vachiéry, R. Tedford   +7 more
semanticscholar   +1 more source

Pulmonary hypertension in children with congenital heart disease (PAH-CHD, PPHVD-CHD). Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK

Heart, 2016
Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a complex disease that presents with a broad spectrum of morphological and haemodynamic findings of varying severity.
R. Kozlik-Feldmann, G. Hansmann, D. Bonnet, D. Schranz, C. Apitz, I. Michel-Behnke   +5 more
semanticscholar   +1 more source

Targeted therapy with phosphodiesterase 5 inhibitors in patients with pulmonary hypertension due to heart failure and elevated pulmonary vascular resistance: a systematic review

Pulmonary Circulation, 2020
Pulmonary Hypertension due to left heart disease is the most common type of Pulmonary Hypertension. Morbidity and mortality significantly increase once Pulmonary Hypertension is present.
Galo M. Sanchez Palacios, Cindy Schmidt, Tammy Wichman   +2 more
doaj   +1 more source

Riociguat for pulmonary arterial hypertension associated with congenital heart disease

Heart, 2015
Objective The Pulmonary Arterial hyperTENsion sGC-stimulator Trial-1 (PATENT-1) was a randomised, double-blind, placebo-controlled phase III trial evaluating riociguat in patients with pulmonary arterial hypertension (PAH).
S. Rosenkranz, H. Ghofrani, M. Beghetti, D. Ivy, R. Frey, A. Fritsch, G. Weimann, S. Saleh, C. Apitz   +8 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Prognosis and Treatment With Phosphodiesterase 5 Inhibitors in Combined Post‐ and Precapillary Pulmonary Hypertension: A Propensity Score‐Matched Analysis From the Hellenic Pulmonary Hypertension Registry

Pulmonary Circulation
Combined post‐ and precapillary pulmonary hypertension (CpcPH) comprises the most severe form of postcapillary PH. A severe precapillary component (pulmonary vascular resistance [PVR] > 5 WU) is critical for therapeutic decisions.
Georgios E. Papadopoulos, Alexandra Arvanitaki, Sophia‐Anastasia Mouratoglou, Panagiotis Gourgiotis, Thomas Chrysochoidis‐Trantas, Athena Mpatsouli, Aris Bechlioulis, Aikaterini Naka, Eftychia Demerouti, Panagiotis Karyofyllis, Dimitrios Tsiapras, Anastasia Anthi, Athanasios Manginas, Antonios Ziakas, Stephan Rosenkranz, George Giannakoulas   +15 more
doaj   +1 more source

Correction of therapy of concerned cardiovascular disease and chronic obstructive pulmonary disease in a patient with pulmonary tuberculosis

Клинический разбор в общей медицине, 2021
Chronic obstructive pulmonary disease and cardiovascular diseases (arterial hypertension, coronary heart disease, chronic heart failure) are among the comorbid conditions that mutually aggravate each other.
Natalia V. Bagisheva , Anna V. Mordyk, Dmitry I. Trukhan , Inna A. Viktorova, Marina V. Moiseeva , Anna R. Aroyan, Svetlana V. Sitnikova   +6 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source