Results 131 to 140 of about 700,247 (353)

Enhancing Anti‐Tumor Effects of Engineered Extracellular Vesicles via Endocytosis Route Switching and Interferon Response Suppression

Advanced Science, EarlyView.
CD19‐293‐EV can switch the CD19 endocytosis pathway from clathrin‐mediated endocytosis to aggregation‐dependent endocytosis, leading to lysosomal degradation of the CD19/EVs complex. Degradation of the EVs leads to impairment in the IFN response and enhancement in EV uptake by target cells, creating a potent feedback cycle.
Zixuan Huang, Chaoqun Lu, Yixin Wang, Huajian Xian, Yuling Zheng, Ting Kang, Rufang Xiang, Shufeng Xie, Minghui Wang, Zeyi Li, Xiaoli Xia, Yaoyifu Yu, Wenjie Zhang, Huijian Zheng, Renyao Pan, Dan Li, Chunjun Zhao, Han Liu   +17 more
wiley   +1 more source

HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension

Scientific Reports, 2017
Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with limited therapeutic options. Although exposed to stressful conditions, pulmonary artery (PA) smooth muscle cells (PASMCs) exhibit a “cancer-like” pro-proliferative and anti ...
Olivier Boucherat, Sophie Chabot, Roxane Paulin, Isabelle Trinh, Alice Bourgeois, François Potus, Marie-Claude Lampron, Caroline Lambert, Sandra Breuils-Bonnet, Valérie Nadeau, Renée Paradis, Elena A. Goncharova, Steeve Provencher, Sébastien Bonnet   +13 more
doaj   +1 more source

The Mechanism and Potential Therapeutic Strategies of Vascular Aging

AGING MEDICINE, EarlyView.
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu, Xuan Wang, Fang‐Fang Wu, Xiao‐Tian Yan, Yong‐Ping Bai   +4 more
wiley   +1 more source

Cardiopulmonary Exercise Testing With Simultaneous Echocardiography After Pulmonary Embolism

Pulmonary Circulation
Although current guidelines recommend standard cardiopulmonary exercise testing (CPET) to evaluate symptomatic patients after pulmonary embolism (PE), CPET with simultaneous echocardiography could provide relevant information to evaluate right ...
Karys Khilzi, Lucilla Piccari, Gerard Franco, Anna Rodó‐Pin, Anna Herranz, Isabel Blanco, Giuseppe Paciocco, Lorenzo Volpiano, Jose Gonzalez Garcia, Ana Diez‐Llaneza, Lluis Molina, Diego A. Rodríguez Chiaradía   +11 more
doaj   +1 more source

PULMONARY HYPERTENSION IN CONGENITAL HEART DISEASE [PDF]

, 1958
W. Evans, D Short
openalex   +1 more source

Analysis of Outcomes in Pancreaticoduodenectomy for Elderly Patients Aged 80 and Above: A Retrospective Study Using Inverse Probability of Treatment Weighting

AGING MEDICINE, EarlyView.
This graphic summary shows the main clinical outcomes of patients over 80 years of age following pancreaticoduodenectomy (PD) after adjusting for propensity score weighting (IPTW). Compared with younger patients, there was no significant difference in postoperative complication rates or overall survival time in elders. ABSTRACT Objectives With an aging
Tianxiao Wang, Yue Qiu, Yingjixing Luo, Ruili Wei, Li Xu, Jia Huang, Wenying Zhou, Hanchun Huang, Yongliang Sun, Zhiying Yang   +9 more
wiley   +1 more source

Pulmonary vascular disease, environmental pollution, and climate change

Pulmonary Circulation
Pollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory ...
Mona Lichtblau, Lena Reimann, Lucilla Piccari   +2 more
doaj   +1 more source

Pulmonary Hypertension and a Continuous Murmur Due to Multiple Peripheral Stenoses of the Pulmonary Arteries [PDF]

, 1958
William G. Smith
openalex   +1 more source

Impact of Intraoperative Fluid Volume on Complications After Minimally Invasive Esophagectomy: Analysis of 8782 Patients From the Japanese National Clinical Database

Annals of Gastroenterological Surgery, EarlyView.
This multicenter cohort study of 8782 esophagectomies in Japan found that higher intraoperative fluid volume significantly increased the risk of pneumonia after minimally invasive esophagectomy. Avoiding fluid overload may help reduce postoperative pneumonia.
Akihiko Okamura, Hideki Endo, Masayuki Watanabe, Hiroyuki Yamamoto, Hirotoshi Kikuchi, Naoki Yoshimura, Hideki Ueno, Masayuki Chida, Ken Shirabe   +8 more
wiley   +1 more source

High-risk pregnancy in a patient with pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) with temporary shunt inversion and deoxygenation

Pulmonary Circulation, 2019
Atrial septal defect (ASD) is one of the most frequent congenital heart diseases (CHD). Up to 10% of adults with an ASD develop pulmonary arterial hypertension (PAH, PAH-CHD) in their lifetime.
Christopher Hohmann, Daniel Dumitrescu, Felix Gerhardt, Tilmann Kramer, Stephan Rosenkranz, Michael Huntgeburth   +5 more
doaj   +1 more source