Results 131 to 140 of about 2,498,926 (399)

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Effect of ambrisentan in patients with systemic sclerosis and mild pulmonary arterial hypertension: long-term follow-up data from EDITA study

Arthritis Research & Therapy
Background In the EDITA trial, patients with systemic sclerosis (SSc) and mild pulmonary vascular disease (PVD) treated with ambrisentan had a significant decline of pulmonary vascular resistance (PVR) but not of mean pulmonary arterial pressure (mPAP ...
Panagiota Xanthouli, Paul Uesbeck, Hanns-Martin Lorenz, Norbert Blank, Christina A. Eichstaedt, Satenik Harutyunova, Benjamin Egenlauf, Jerry G. Coghlan, Christopher P. Denton, Ekkehard Grünig, Nicola Benjamin   +10 more
doaj   +1 more source

Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension [PDF]

, 2016
BACKGROUND: Right ventricular (RV) function is a major determinant of exercise intolerance and outcome in idiopathic pulmonary arterial hypertension (IPAH). The aim of the study was to evaluate the incremental prognostic value of echocardiography of the
Badagliacca, Roberto, Fedele, Francesco, Giannetta, E, Manzi, G, Naeije, R, Palange, Paolo, Papa, S, Pezzuto, Beatrice, Poscia, Roberto, Sciomer, S, Valli, G, Vizza, Carmine Dario   +11 more
core   +1 more source

Statement on imaging and pulmonary hypertension from the Pulmonary Vascular Research Institute (PVRI)

Pulmonary Circulation, 2019
Pulmonary hypertension (PH) is highly heterogeneous and despite treatment advances it remains a life-shortening condition. There have been significant advances in imaging technologies, but despite evidence of their potential clinical utility, practice ...
D. Kiely, D. Levin, P. Hassoun, D. Ivy, P. Jone, J. Bwika, S. Kawut, J. Lordan, A. Lungu, J. Mazurek, S. Moledina, H. Olschewski, A. Peacock, G. Puri, F. Rahaghi, M. Schafer, M. Schiebler, N. Screaton, M. Tawhai, E. V. van Beek, A. Vonk-Noordegraaf, R. Vanderpool, J. Wort, Lan Zhao, J. Wild, J. Vogel-Claussen, A. Swift   +26 more
semanticscholar   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Emerging role of angiogenesis in adaptive and maladaptive right ventricular remodeling in pulmonary hypertension [PDF]

, 2018
Right ventricular (RV) function is the primary prognostic factor for both morbidity and mortality in pulmonary hypertension (PH). RV hypertrophy is initially an adaptive physiological response to increased overload; however, with persistent and/or ...
Bonnet, Sébastien, de Jesus Perez, Vinicio A., Frump, Andrea L., Lahm, Tim   +3 more
core   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Prediction of Prognostic Hemodynamic Indices in Pulmonary Hypertension Using Non-Invasive Parameters

Diagnostics, 2020
Effective targeted therapy of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) requires regular risk stratification.
Rafał Mańczak, Marcin Kurzyna, Michał Piłka, Szymon Darocha, Michał Florczyk, Maria Wieteska-Miłek, Małgorzata Mańczak, Adam Torbicki   +7 more
doaj   +1 more source

Pulmonary hypertension

Nature Reviews Disease Primers
Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to elevated pressures within the pulmonary arteries. Five main groups of pulmonary hypertension are recognized, all defined by a mean pulmonary artery pressure of >20 mmHg: pulmonary arterial hypertension (rare), pulmonary hypertension associated with left-sided ...
Ana Mocumbi, Marc Humbert, Anita Saxena, Zhi-Cheng Jing, Karen Sliwa, Friedrich Thienemann, Stephen L. Archer, Simon Stewart   +7 more
openaire   +3 more sources

Pulmonary Hypertension

Deutsches Ärzteblatt international, 2017
About 1% of adults suffer from pulmonary hypertension (PH). The various types of PH differ widely with respect to their incidence, clinical significance, and treatment.Selective review of the literature in association with a consensus conference.Pulmonary hypertension is divided into five major categories.
Marius M, Hoeper, Hossein-Ardeschir, Ghofrani, Ekkehard, Grünig, Hans, Klose, Horst, Olschewski, Stephan, Rosenkranz   +5 more
openaire   +2 more sources