Results 111 to 120 of about 1,353,059 (301)

Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model

, 2020
The pathogenesis of pulmonary arterial hypertension is closely associated with dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition and function were reported in a pulmonary arterial hypertension experimental animal ...
Sakao, Seiichiro, Sanada, Takayuki J., Hosomi, Koji, Miwa, Hideki, Kobayashi, Takayuki, Suda, Rika, Yanagisawa, Asako, Tanabe, Nobuhiro, Shoji, Hiroki, Naito, Akira, Park, Jonguk, Tatsumi, Koichiro, Ikubo, Yumiko, Kunisawa, Jun, Mizuguchi, Kenji   +14 more
core   +1 more source

DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells

Physiological Reports, 2019
Nitric Oxide (NO) is an endogenous pulmonary vasodilator produced by endothelial NO synthase (eNOS). Asymmetric dimethyl L‐arginine (ADMA) is an endogenous inhibitor of eNOS activity.
Jennifer K. Trittmann, Hanadi Almazroue, Yi Jin, Leif D. Nelin   +3 more
doaj   +1 more source

Comparison of Minimally Invasive Colectomy Between Intra‐ Versus Extra‐Corporeal Anastomosis Technique (COMMIT Study): Short‐Term Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter propensity score‐matched study of 3213 patients compared intracorporeal (IA) and extracorporeal (EA) anastomosis during minimally invasive colectomy. IA was associated with a significantly lower incidence of intraoperative blood loss ≥ 200 mL (2.5% vs.
Takuya Takami, Takehito Yamamoto, Yoshiro Itatani, Ryosuke Mizuno, Kae Okoshi, Yasunori Deguchi, Keiji Nagata, Tomoaki Okada, Rei Mizuno, Kazutaka Obama   +9 more
wiley   +1 more source

Exploring the Endothelin-1 pathway in chronic thromboembolic pulmonary hypertension microvasculopathy

Scientific Reports
Targeted vasopeptide therapies have significantly advanced the management of pulmonary arterial hypertension (PAH). However, due to insufficient preclinical evidence regarding the involvement of the endothelin-1 (ET-1) pathway in chronic thromboembolic ...
Benchenouf Feriel, Cuomo Alessandra, Gorth J. Deborah, Normand Corinne, Thuillet Raphaël, Ottaviani Mina, Akamkam Ali, Menager Jean-Baptiste, Fadel Guillaume, Grynblat Julien, Ghigna Maria-Rosa, Fadel Elie, Savale Laurent, Mercier Olaf, Tu Ly, Humbert Marc, Guignabert Christophe   +16 more
doaj   +1 more source

Sarcopenia in Patients with Chronic Thromboembolic Pulmonary Hypertension

Journal of Cardiovascular Development and Disease
Background: Sarcopenia, or loss of skeletal muscle mass, has been associated with poor outcomes (e.g., functional decline, increased mortality, and low quality of life), but its role in CTEPH remains unclear.
Steven Hopkins, Jillian Hall, Hollie Saunders, Riyaz Bashir, Vladimir Lakhter, Anjali Vaidya, Ahmed Sadek, Paul Forfia, Estefania Oliveros   +8 more
doaj   +1 more source

Radical Resection of the Third Portion of the Duodenum for Secondary Aortoduodenal Fistula

Annals of Gastroenterological Surgery, EarlyView.
Secondary aortoduodenal fistula most commonly involves the third portion of the duodenum and requires definitive management of both vascular and gastrointestinal components. We demonstrate a step‐by‐step technique for radical duodenal resection and reconstruction performed in structured collaboration with cardiovascular surgeons.
Koji Kubota, Akira Shimizu, Tsuyoshi Notake, Tatsuichiro Seto, Yuji Soejima   +4 more
wiley   +1 more source

New advances in the treatment of pulmonary hypertension

, 2020
Pulmonary hypertension is a chronic disease with a devastating outcome. It is characterized by remodeling mechanisms that leads to an increase in vascular resistance of the pulmonary arterioles.
Shacham, Mor
core  

New advances in the treatment of pulmonary hypertension

, 2021
New and old agents for the treatment of pulmonary hypertension. The focus is on the novel agents under the investigation of their target and mode of action and their effectiveness for each type of pulmonary hypertension and as well as the promises they ...
Yoon, Adrian Hyeukjin
core  

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source