Results 91 to 100 of about 1,353,059 (301)

Cellular senescence in adult pulmonary hypertension: current state and future challenges

European Respiratory Review
Pulmonary hypertension (PH) is a life-threatening disease increasingly being diagnosed in the elderly population, marked by vascular injury, excessive vasoconstriction and progressive remodelling of the pulmonary arteries (PAs).
Sarah-Eve Lemay, Yukimitsu Kuwabara, Sébastien Bonnet, François Potus, Steeve Provencher, Serge Adnot, Olivier Boucherat   +6 more
doaj   +1 more source

Toward Perception‐Native Electronic Skin: Bio‐Inspired In‐/Near‐Sensor and Neuromorphic Computing for Humanoid Robots

Advanced Materials Technologies, EarlyView.
Dense tactile streams from across the humanoid body converge on collide in a central wiring and data bottleneck. By relocating computation closer to and then into the skin itself, near‐ and in‐sensor architectures, together with neuromorphic computing, chart a path toward perception‐native electronic skin, in which the conversion of stimulus into ...
Mijin Kim, Chang‐Jae Beak, Jiyoung Park, Youngdo Jung, Sunjong Oh, Sin‐Hyung Lee, Bo‐Yeon Lee   +6 more
wiley   +1 more source

Inoperable chronic thromboembolic pulmonary hypertension treated with riociguat: A case study

Revista Portuguesa de Cardiologia, 2015
A 51-year-old woman presented with a one-year history of progressive dyspnea, WHO functional class III-IV and exercise-related syncope. Transthoracic echocardiography and computed tomography pulmonary angiography were performed, leading to a diagnosis of
Carlos Ortiz-Bautista, Nuria Ochoa-Parra, Paula Navas-Tejedor, Laura Morán-Fernández, Miguel Ángel Gómez-Sánchez   +4 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency. [PDF]

, 2015
In patients with idiopathic pulmonary arterial hypertension (iPAH), iron deficiency is common and has been associated with reduced exercise capacity and worse survival. Previous studies have shown beneficial effects of intravenous iron administration. In
Ruiter, G, van der Laarse, W.J., Howard, LS, Vonk‐Noordegraaf Anton, Chris M. Happé, Happe, C.M., Luke S. Howard, Westerhof, N, Schalij, I, Howard, L.S., Wilkins, MR, Emmy Manders, Ruiter, G., van der Laarse, WJ, Westerhof, N., Schalij, I., Manders, E, Happé, CM, Harm J. Bogaard, Bogaard, HJ, de Man, FS, Wilkins, M.R., Groepenhoff, H, Bogaard, H.J., de Man, F.S., Gerrina Ruiter, Herman Groepenhoff, Frances S. de Man, Vonk-Noordegraaf, A, Vonk-Noordegraaf, A., Willem J. van der Laarse, Ingrid Schalij, Manders, E., Groepenhoff, H., Nico Westerhof, Martin R. Wilkins   +35 more
core   +1 more source

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

, 2021
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH ...

core   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Chronic thromboembolic pulmonary hypertension from the perspective of patients with pulmonary embolism [PDF]

, 2018
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but feared long-term complication of acute pulmonary embolism (PE), although CTEPH may occur in patients with no history of symptomatic venous thromboembolism.
M. Delcroix, Klok, F A, Bogaard, H.J., Delcroix, M., Bogaard, H J, Delcroix, M, Klok, F.A., F.A. Klok, H.J. Bogaard   +8 more
core   +1 more source

Pulmonary hypertension

Swiss Medical Weekly, 2003
Pulmonary arterial hypertension (PAH) must be classified into primary pulmonary hypertension and PAH related to other diseases such as collagen vascular diseases, HIV infection or portal hypertension. PAH must also be differentiated from other entities, in particular pulmonary hypertension secondary to thromboembolic diseases, requiring specific ...
openaire   +3 more sources