Results 101 to 110 of about 424,390 (258)

Dasatinib‐Induced Pulmonary Arterial Hypertension in Chronic Myeloid Leukaemia: A Case Report and Literature Review

Respirology Case Reports
Dasatinib, a second‐generation tyrosine kinase inhibitor used for treating chronic myeloid leukaemia (CML), is associated with rare but significant adverse effects, including pulmonary arterial hypertension.
Sathish Krishnan, Sashi Adigopula
doaj   +1 more source

Ischemia-reperfusion injury with a model of porcine whole-blood ex-vivo lung perfusion

Frontiers in Transplantation
IntroductionOur objective was to model Ischemia-Reperfusion (IR) injuries by ex-vivo perfusion of porcine lungs with whole blood containing the inflammatory cells.MethodsLungs and whole blood were collected from 12 pigs and submitted to cold ischemia ...
Jean-Baptiste Menager, Jean-Baptiste Menager, Jean-Baptiste Menager, Julia Mercier, Julia Mercier, Justin Issard, Justin Issard, Justin Issard, Maria-Rosa Ghigna, Maria-Rosa Ghigna, Maria-Rosa Ghigna, Jeanne Tran Van Nhieu, Benoit Decante, Benoit Decante, Julien Guihaire, Julien Guihaire, Elie Fadel, Elie Fadel, Elie Fadel, Fabrice Antigny, Fabrice Antigny, Olaf Mercier, Olaf Mercier, Olaf Mercier   +23 more
doaj   +1 more source

Allergic Rhinitis Amplifies Asthma Risk in Patients With Chronic Rhinosinusitis: A Large‐Scale Retrospective Cohort Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are two highly prevalent airway diseases in the United States. While the coexistence of CRS and asthma is well recognized, less is known about the development of new‐onset asthma in CRS, particularly in the context of comorbid AR. This study assessed the impact of CRS and AR on
Austin J. Lee, Mohamad R. Chaaban
wiley   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Protein biomarkers in pulmonary arterial hypertension: advances, clinical relevance, and translational challenges

Journal of Translational Medicine
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by pulmonary vasoconstriction and right ventricular dysfunction.
Yanqin Niu, Jinglin Tian, Steeve Provencher, Sebastien Bonnet, Olivier Boucherat, François Potus, Deming Gou   +6 more
doaj   +1 more source

A Comparison of Frailty Indices in Predicting Postoperative Outcomes After Endoscopic Sinus Surgery

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Objective To compare the discriminatory performance of the Risk Analysis Index (RAI) and modified Frailty Index‐5 (mFI‐5) in predicting postoperative outcomes following endoscopic sinus surgery (ESS). Study Design Retrospective cohort study. Methods Adult ESS patients were identified from the ACS‐NSQIP database (2005–2020).
Akshay Warrier, David Remyes, Tenesha Boyd, Ailish Nagpal, Aman M Patel, David W. Wassef, Jean Anderson Eloy   +6 more
wiley   +1 more source

A novel rat model of pulmonary artery embolism and the application value of lung ultrasound B‐lines in early‐stage pulmonary embolism

Animal Models and Experimental Medicine, EarlyView.
We report a novel embolus‐induced PE rat model prepared via the inferior vena cava under ultrasound guidance. The embolus employed featured a tubular plastic casing filled with thrombus. By minimizing the contact surface between plasmin and thrombus, it effectively restrains the elevated plasmin activity in rats.
Huide Ma, Shuangrui Wang, Honghui Li, Yaxing Zhang, Yuman Gao, Jie Zhou, Xia Xu, Rong Wu   +7 more
wiley   +1 more source

Comparable Infection Risk of Ocrelizumab and Rituximab in Multiple Sclerosis in a Nationwide Swedish Cohort Study

Annals of Neurology, EarlyView.
In multiple sclerosis (MS), anti‐CD20 therapies have been associated with increased infection risk, but whether this risk differs between rituximab and ocrelizumab is not known. Using a nationwide cohort, we studied infection risk and relapse outcomes among 16,872 treatment episodes with rituximab, ocrelizumab, or other disease‐modifying therapies ...
Thomas Frisell, Sebastian Hedberg, Fredrik Piehl   +2 more
wiley   +1 more source

Pulmonary Hypertension [PDF]

JAMA, 2021
openaire   +2 more sources

Nontobacco Nicotine Dependence Is Associated With Perioperative Complications and Repeat Surgery After Arthroscopic Rotator Cuff Repair

Arthroscopy, EarlyView.
Purpose To compare perioperative complications and revision surgery rates between following primary rotator cuff repair among patients with nontobacco nicotine dependence (NTND), no nicotine dependence, and traditional tobacco‐related nicotine dependence.
Samuel A. Florentino, Alexander N. Berk, Logan M. Good, Jeremy M. Adelstein, Robert J. Wetzel, George Ochenjele, Joshua K. Napora   +6 more
wiley   +1 more source