Results 61 to 70 of about 104,967 (312)

Inhaled Gene Transfer for Pulmonary Circulation [PDF]

, 2016
Chronic pulmonary hypertension (PH) is associated with right ventricular failure and high mortality regardless of the underlying disease. Currently, therapies can improve clinical outcomes in specific subsets of patients, but have little impact on the progression of pulmonary vascular remodeling.
Jaume, Aguero, Lahouaria, Hadri, Nadjib, Hammoudi, Lauren, Leonardson, Roger J, Hajjar, Kiyotake, Ishikawa   +5 more
openaire   +2 more sources

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source

Inhaled Corticosteroid Rapidly Improved Pulmonary Sarcoidosis

Internal Medicine, 2005
We report two cases in whom inhaled corticosteroid rapidly improved pulmonary sarcoidosis. In the first case, fluticasone at 400 microg/day was initiated, because dry cough and small nodular shadows on chest X-ray persisted for six months. But her cough and the nodular shadows were persisted, therefore the treatment was replaced with budesonide at 800 ...
Shoji, Ohno, Shoko, Nakazawa, Akira, Kobayashi, Hideaki, Yamasawa, Masashi, Bando, Yukihiko, Sugiyama   +5 more
openaire   +3 more sources

Artificial Intelligence‐Driven Soft Bioelectronics for Self‐Powered Respiration Monitoring

Advanced Science, EarlyView.
Artificial intelligence‐driven soft bioelectronics for self powered respiration monitoring based on triboelectric nanogenerators (TENGs), piezoelectric nanogenerators (PENGs), and magnetoelastic generators (MEGs) enable continuous and multi‐scenario respiratory biomechanical data collection. Coupled with machine learning and big data driven diagnostics,
Xinkai Xu, Xiao Xiao, Rui Guo, Jun Chen
wiley   +1 more source

Noninvasive Positive Pressure Ventilation against Reperfusion Pulmonary Edema following Percutaneous Transluminal Pulmonary Angioplasty

Case Reports in Anesthesiology, 2011
A 69-year-old man with chronic thromboembolic pulmonary hypertension (CTEPH) was on amblatory oxygen inhalation therapy (3 L/min) and scheduled for percutaneous transluminal pulmonary angioplasty (PTPA).
Kiyoshi Moriyama, Sayuri Sugiyama, Koji Uzawa, Mariko Kotani, Toru Satoh, Tomoko Yorozu   +5 more
doaj   +1 more source

Inhaled therapy for the management of perioperative pulmonary hypertension

Annals of Cardiac Anaesthesia, 2015
Patients with pulmonary hypertension (PH) are at high risk for complications in the perioperative setting and often receive vasodilators to control elevated pulmonary artery pressure (PAP).
C A Thunberg, S T Morozowich, Harish Ramakrishna   +2 more
doaj   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Spore-inspired inhalation drug delivery system for asthma therapy

Bioactive Materials
The delivery efficiency of drugs in the lung is crucial for inhaled therapies targeting pulmonary diseases. However, current inhalation carriers face challenges overcoming pulmonary barriers, leading to insufficient delivery efficiency.
Mengqi Tong, Xi Kuang, Qiaoying Jiang, Gaoxiang Li, Lulu Jin, Yihao Ye, Yi Pan, Yang Zhu, Xiaozhou Mou, Zhengwei Mao, Yueliang Zheng   +10 more
doaj   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Inhalation of β2 agonists impairs the clearance of nontypable Haemophilus influenzae from the murine respiratory tract

Respiratory Research, 2006
Background Nontypable Haemophilus influenzae (NTHi) is a common bacterial pathogen causing human respiratory tract infections under permissive conditions such as chronic obstructive pulmonary disease.
de Vos Alex F, van't Veer Cornelis, Florquin Sandrine, Maris Nico A, Buurman Wim, Jansen Henk M, van der Poll Tom   +6 more
doaj   +1 more source