Results 171 to 180 of about 1,214,442 (354)

Real‐Time Evolutionary Landscape of the Bronchial Epithelium and Corresponding Dynamic Immune Cell Alterations in Lung Squamous Cell Carcinogenesis

open access: yesAdvanced Science, EarlyView.
Lung squamous cell carcinoma (LUSC) is often preceded by sequential premalignant lesions with an increasing probability of malignant progression. Using single‐cell RNA sequencing, the dynamic cellular evolution from normal lung to LUSC tissues is delineated; clonal structure of premalignant and malignant epithelium is reveled; the conversion of immune ...
Baohong Luo   +16 more
wiley   +1 more source

Severe COPD: Multidisciplinary Consultation to Get the Right Care at the Right Place

open access: yesInternational Journal of COPD
Pieter-Paul Hekking,1 Monique van Meggelen,1 W Johan Lie,2 Rogier Arnaud Sebastiaan Hoek,3,4 Dirk van Ranst,5 Stephan Cornelis Johan van der Kleij,6 Leonard Seghers,4 Jasper Kappen,1,7 Gert-Jan Braunstahl,1,8 Johannes In ’t Veen1 On behalf of Severe ...
Hekking PP   +9 more
doaj  

Treatment of pulmonary exacerbations in cystic fibrosis. [PDF]

open access: yesCurr Opin Pulm Med, 2020
Ng C, Nadig T, Smyth AR, Flume P.
europepmc   +1 more source

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

open access: yesAdvanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang   +10 more
wiley   +1 more source

Effects of biomass smoke on pulmonary functions: a case control study

open access: yesInternational Journal of COPD, 2016
Baran Balcan,1 Selcuk Akan,2 Aylin Ozsancak Ugurlu,1 Bahar Ozcelik Handemir,3 Berrin Bagcı Ceyhan,4 Sevket Ozkaya5 1Department of Pulmonary Medicine, Baskent University Faculty of Medicine, Istanbul, 2Department of Internal Medicine, Ankara Education ...
Balcan B   +5 more
doaj  

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang   +6 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

open access: yesAdvanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu   +13 more
wiley   +1 more source

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