Results 51 to 60 of about 45,869 (242)

SP-D counteracts GM-CSF-mediated increase of granuloma formation by alveolar macrophages in lysinuric protein intolerance

Orphanet Journal of Rare Diseases, 2009
Background Pulmonary alveolar proteinosis (PAP) is a syndrome with multiple etiologies and is often deadly in lysinuric protein intolerance (LPI). At present, PAP is treated by whole lung lavage or with granulocyte/monocyte colony stimulating factor (GM ...
Grasemann Hartmut, Dell Sharon, Farmakovski Nicole, Douda David N, Palaniyar Nades   +4 more
doaj   +1 more source

Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration. [PDF]

, 2015
BackgroundCurrent neonatal resuscitation guidelines recommend tracheal suctioning of nonvigorous neonates born through meconium-stained amniotic fluid.MethodsWe evaluated the effect of tracheal suctioning at birth in 29 lambs with asphyxia induced by ...
Gugino, Sylvia F, Koenigsknecht, Carmon, Lakshminrusimha, Satyan, Mathew, Bobby, Nair, Jayasree, Nielsen, Lori, Rawat, Munmun, Swartz, Daniel D   +7 more
core  

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

Surfactant Protein-D Is Essential for Immunity to Helminth Infection.

PLoS Pathogens, 2016
Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D).
Sumaiyya Thawer, Jennifer Auret, Corinna Schnoeller, Alisha Chetty, Katherine Smith, Matthew Darby, Luke Roberts, Rosie-Marie Mackay, Harry J Whitwell, John F Timms, Jens Madsen, Murray E Selkirk, Frank Brombacher, Howard William Clark, William G C Horsnell   +14 more
doaj   +1 more source

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats [PDF]

, 2016
The increasing use of silver nanoparticles (AgNPs) in consumer products is concerning. We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to Sprague-Dawley (SD) rats.We determined the ...
Buckley, A, Chung, KF, Dai, R, Gong, J, Gow, A, Guo, C, Hodgson, A, Hussain, F, Leo, B, Martin, NG, Porter, A, Ryan, M, Seiffert, J, Smith, R, Tetley, T, Warren, J, Zhang, J, Zhu, J   +17 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Surfactant Protein D as a Potential Biomarker and Therapeutic Target in Ovarian Cancer

Frontiers in Oncology, 2019
Surfactant protein D (SP-D) is an important innate immune molecule that is involved in clearing pathogens and regulating inflammation at pulmonary as well as extra-pulmonary sites.
Juhi Kumar, Valamarthy Murugaiah, Georgios Sotiriadis, Anuvinder Kaur, Jeyarooban Jeyaneethi, Isotta Sturniolo, Fatimah S. Alhamlan, Jayanta Chatterjee, Marcia Hall, Marcia Hall, Uday Kishore, Emmanouil Karteris, Emmanouil Karteris   +12 more
doaj   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate idiopathic pulmonary fibrosis from idiopathic nonspecific interstitial pneumonia

Scientific Reports, 2021
Circulating monocytes have pathogenic relevance in idiopathic pulmonary fibrosis (IPF). Here, we determined whether the cell surface levels of two markers, pro-inflammatory-related S100A9 and anti-inflammatory-related CD163, expressed on CD14strongCD16 ...
Masahiro Yamashita, Yuh Utsumi, Hiromi Nagashima, Hiroo Nitanai, Kohei Yamauchi   +4 more
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source