Results 191 to 200 of about 75,950 (297)

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Effects of Nicotine on the Thermodynamics and Phase Coexistence of Pulmonary Surfactant Model Membranes. [PDF]

Membranes (Basel)
Magalhães FSS, Vieira ED, Batista MRB, Costa-Filho AJ, Basso LGM.   +4 more
europepmc   +1 more source

Plasma supplemented with glycine is superior to standard plasma in reducing vascular permeability and organ injury via reduction of inflammation in an experimental traumatic shock model

Transfusion, EarlyView.
Abstract Background While plasma transfusion is a key resuscitation strategy, its mechanisms of benefit beyond coagulopathy correction remain unclear. Solvent detergent plasma, which contains high glycine levels and lacks inflammatory mediators, may offer advantages over fresh frozen plasma by preserving endothelial integrity and reducing inflammation.
Tarık Gözden, Bülent Ergin, Gözdenur Güneş, Ayşegül Kapucu, Nicole Juffermans   +4 more
wiley   +1 more source

Efficacy of pulmonary surfactant with budesonide in premature infants: A systematic review and meta-analysis. [PDF]

PLoS One
Phattraprayoon N, Tan B, Na Takuathung M.   +2 more
europepmc   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Comparative Efficacy and Safety Profile of the Combination of Pulmonary Surfactant and Budesonide vs. Surfactant Alone in the Management of Neonatal Respiratory Distress Syndrome: An Updated Meta-Analysis. [PDF]

Medicina (Kaunas)
Fatima U, Naveed N, Riaz Z, Khalid E, Qamer A, Baig S, Fatima R, Hussain A, Mustunsar Z, Khan A, Mangan S, Kumari M, Ali Qasim S, Hasan A, Ahmed R.   +14 more
europepmc   +1 more source

Successful Treatment of Acute Respiratory Distress Syndrome in an 8‐Day‐Old Standardbred Foal With Intratracheal Oxygen Therapy via Temporary Tracheostomy

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective This report describes an 8‐day‐old foal diagnosed with acute respiratory distress syndrome (ARDS) successfully managed using a novel approach of intratracheal oxygen delivery. Case Summary An 8‐day‐old Standardbred filly presented for an acute onset of respiratory distress. Given the acute onset, known risk factors, bilateral diffuse
Megan G. Palmisano, Caitlyn R. Tukdarian, Klaus Hopster, Rose D. Nolen‐Walston   +3 more
wiley   +1 more source

Structural determinants of collapse by a monomolecular mimic of pulmonary surfactant at the physiological temperature. [PDF]

Soft Matter
Dayeen FR, Brandner BA, Bu W, Hall SB, Gidalevitz D.   +4 more
europepmc   +1 more source

Retrospective Evaluation of the Association of Pulmonary Contusion Volume as Assessed by Computed Tomography With Mortality and Provision of Mechanical Ventilation in Traumatized Dogs (2019–2023): 27 Cases

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objectives To evaluate the association between the percentage of pulmonary contusion volume (PPCV) found on computed tomography (CT) and survival to discharge or implementation of mechanical ventilation (MV) in a cohort of dogs with thoracic trauma. Design Retrospective multicenter study (March 2019 to April 2023).
Alicia Álvarez‐Punzano, Anna Palomares, Miriam Martínez, Noemi Gómez‐Martínez, Rosa Novellas, Yvonne Espada, Luis Bosch‐Lozano, Vicente Herrería‐Bustillo   +7 more
wiley   +1 more source

Pulmonary surfactant.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980
M, Garrigues, A, Neidhart, J, Vanche
openaire   +3 more sources