Results 131 to 140 of about 1,493,409 (315)

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Mutagenicity of diesel exhaust soot dispersed in phospholipid surfactants

, 1994
Organics extractable from respirable diesel exhaust soot particles by organic solvents have been known for some time to be direct acting frameshift mutagens in the Ames Salmonella typhimurium histidine reversion assay.
Xing, S., Ong, T., Gautam, M., Harrison, J., Keane, M., Wallace, W.   +5 more
core   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Impact of Different Pre‐Dilution Methods on Routine Blood Test Results: A Study With Sysmex XN‐1000

Journal of Clinical Laboratory Analysis, EarlyView.
The wet wipe method demonstrated excellent consistency with automated injection across all five parameters and is recommended as the preferred technique when sample volume is limited. ABSTRACT Objectives To compare three manual pre‐dilution procedures with the automated undiluted mode on the Sysmex XN‐1000 analyzer and to identify an optimal standard ...
Lingsong Wu, Mengzhe Qin, Zhe Xing, Fengli Jiang, Sien Zhan, Jintian Hu   +5 more
wiley   +1 more source

Biophysical and Physiological Properties of Synthetic Surfactants Containing a Surfactant Protein Analog

, 2014
Purpose: The in vitro biophysical and in vivo physiological properties of two synthetic surfactants containing either an SP-B or SP-C analog were compared with those of a modified bovine surfactant preparation, Surfactant-TA (Surfacten).Methods ...
Chida, S.; Department of Pediatrics, Iwate Medical University School of Medicine, Morioka, Japan
core   +1 more source

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

Advances in nanotechnology for the therapy of bacterial pneumonia

Frontiers in Cellular and Infection Microbiology
Bacterial pneumonia, a life-threatening infection, is the world’s sixth deadliest disease and the top cause of mortality in children under five. Without timely treatment, bacterial pneumonia can escalate to a 30% mortality rate, particularly in high-risk
Zihan Tian, Zihan Tian, Yuwei Zhang, Jiachen Yun, Weihong Kuang, Weihong Kuang, Jin Li   +6 more
doaj   +1 more source

Development of novel synthetic lung surfactants for treatment of respiratory distress syndrome

, 2020
Pulmonary surfactant is a complex mixture of lipids and specific proteins found in the alveoli and its main role is to reduce the surface tension of the alveolar air/water interface, thereby preventing lung collapse.
Oihana Basabe Burgos (18654442)
core  

Ginsenoside Rg1 Ameliorates LPS‐Induced Sepsis‐Associated Lung Injury in Mice via VEGFC/D‐VEGFR3 Signaling‐Mediated Lymphangiogenesis and Lymphatic Remodeling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced acute lung injury (ALI) remains challenging to treat, with conventional anti‐inflammatory therapies offering limited efficacy. The lymphatic system is crucial for removing edema and inflammatory mediators, and its impairment can exacerbate lung injury.
He Wang, Lan Hu, Chun‐Pan Zhang, Wen‐Jie Qi, Yu‐Guo Song   +4 more
wiley   +1 more source

Hydrodynamic Cleansing of Pulmonary Alveoli [PDF]

, 2002
The inside wall of the pulmonary alveolus is lined with a thin viscous fluid layer and a monolayer of surfactants. Inhaled foreign particles that reach the lung alveoli are normally neutralized by macrophages and remain inside the lung.
Zelig, D, Haber, S
core