Results 51 to 60 of about 338,921 (264)

Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells

Stem Cells International, 2020
Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient.
Morten Juhl, Bjarke Follin, Monika Gad, Jesper Larsen, Jens Kastrup, Annette Ekblond   +5 more
doaj   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Impact of Stress Hyperglycemia Ratio on Adverse Outcomes in Patients With Chronic Thromboembolic Pulmonary Hypertension

Clinical and Translational Science
Prognostic assessment of chronic thromboembolic pulmonary hypertension (CTEPH) remains challenging. Stress hyperglycemia, a condition where glucose metabolism is regulated during stress, has been regarded as an indicator of acute hyperglycemia.
Yijia Wang, Xin Li, Zhihua Huang, Anqi Duan, Sicheng Zhang, Qi Wang, Sicong Li, Luyang Gao, Qing Zhao, Tao Yang, Zhihui Zhao, Qin Luo, Zhihong Liu   +12 more
doaj   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Tumor biomarkers in evaluating the severity and prognosis of idiopathic pulmonary arterial hypertension: A comprehensive analysis

Clinical and Translational Science
Inflammation contributes to development of idiopathic pulmonary arterial hypertension (IPAH), and tumor biomarkers can reflect inflammatory and immune status. We aimed to determine the value of tumor biomarkers in IPAH comprehensively.
Xin Li, Yi Zhang, Sicheng Zhang, Qing Zhao, Qi Jin, Anqi Duan, Zhihua Huang, Luyang Gao, Yijia Wang, Sicong Li, Zhihui Zhao, Qin Luo, Zhihong Liu   +12 more
doaj   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Effects of malnutrition on disease severity and adverse outcomes in idiopathic pulmonary arterial hypertension: a retrospective cohort study

Respiratory Research
Background Malnutrition is common in patients with chronic cardiovascular disease and is associated with significantly higher all-cause mortality. Approximately one-third of patients with heart failure are malnourished.
Sicheng Zhang, Sicong Li, Luyang Gao, Qing Zhao, Tao Yang, Qixian Zeng, Zhihua Huang, Xin Li, Anqi Duan, Yijia Wang, Zhihui Zhao, Qin Luo, Zhihong Liu   +12 more
doaj   +1 more source

Clinical and prognostic significance of various anemia types in pulmonary arterial hypertension

Frontiers in Medicine
IntroductionCurrent risk models for pulmonary arterial hypertension (PAH) omit anemia, although it may aggravate symptoms and haemodynamics. We assessed whether anemia and its subtypes add prognostic value.MethodsThis study included patients with ...
Marcin Waligóra, Marcin Waligóra, Marcin Waligóra, Maria Mrowicka, Miłosz Pietrus, Justyna Daniek, Patrycja Kurczyna, Michał Karnaś, Weronika Chaba-Karnaś, Kamil Jonas, Kamil Jonas, Kamil Jonas, Grzegorz Kopeć, Grzegorz Kopeć   +13 more
doaj   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Association of Systemic Inflammatory Response Index with Disease Severity and Adverse Outcome in Chronic Thromboembolic Pulmonary Hypertension

Journal of Inflammation Research
Sicong Li,* Luyang Gao,* Sicheng Zhang,* Qing Zhao, Tao Yang, Anqi Duan, Yijia Wang, Qi Wang, Zhihui Zhao, Qin Luo, Zhihong Liu Center for Respiratory and Pulmonary Vascular Diseases, Fuwai Hospital, National Center for ...
Li S, Gao L, Zhang S, Zhao Q, Yang T, Duan A, Wang Y, Wang Q, Zhao Z, Luo Q, Liu Z   +10 more
doaj