Results 151 to 160 of about 159,526 (403)

Vitamin C Intravenous Treatment In the Setting of Atrial Fibrillation Ablation: Results From the Randomized, Double-Blinded, Placebo-Controlled CITRIS-AF Pilot Study [PDF]

, 2020
BackgroundCatheter ablation is an effective treatment for atrial fibrillation (AF), but high levels of post-procedure inflammation predict adverse clinical events.
DeWilde, Christine, Ellenbogen, Kenneth A., Fowler, Alpha, Koneru, Jayanthi N., Priday, Anna, Puckett, Laura, Sculthorpe, Robin, Swift-Scanlan, Theresa, Trankle, Cory R.   +8 more
core   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
wiley   +1 more source

Impact of atrial rhythm on pulmonary vein signals in cryoballoon ablation – Sinus rhythm predicts real-time observation of pulmonary vein isolation

International Journal of Cardiology: Heart & Vasculature, 2019
Purpose: Real-time observation of pulmonary vein (PV) potentials with a spiral mapping catheter has emerged as a key electrogram-based procedural parameter to estimate lesion quality and titrate cryoenergy application during PV isolation (PVI) with the ...
Alexander Pott, Michael Baumhardt, Karolina Weinmann, Manuel Rattka, Tilman Stephan, Mirjam Keßler, Carlo Bothner, Kerstin Petscher, Wolfgang Rottbauer, Tillman Dahme   +9 more
doaj   +1 more source

Recurring patterns of atrial fibrillation in surface ECG predict restoration of sinus rhythm by catheter ablation [PDF]

, 2014
Background Non-invasive tools to help identify patients likely to benefit from catheter ablation (CA) of atrial fibrillation (AF) would facilitate personalised treatment planning.
Bourke, John P., Di Marco, Luigi Yuri, Langley, Philip, Raine, Daniel   +3 more
core   +1 more source

P1909Cryobaloon pulmonary vein isolation without pulmonary venography

European Heart Journal, 2019
Abstract Introduction Cryoballoon pulmonary vein isolation (PVI) has been shown to be non-inferior to radiofrequency PVI and have several advantages including shorter procedure times. Cryoballoon PVI traditionally requires the use of occlusive pulmonary venography to assess for balloon position and ...
C Mengel, X W Lee, J Betts, R Ingram, H M Haqqani   +4 more
openaire   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Safety and Efficacy of Adoptive Transfer of Stem Cell Memory Enriched Virus Specific T Cells against CMV and EBV

Advanced Science, EarlyView.
This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao, Xu‐Ying Pei, Yuan‐Yuan Zhang, Juan Xie, Jing‐Wei Tu, Zhuo‐Jun Liu, Yi‐Yang Ding, Chen‐Hua Yan, Yu‐Hong Chen, Yu Wang, Lan‐Ping Xu, Xiao‐Hui Zhang, Xiao‐Jun Huang, Xiang‐Yu Zhao   +13 more
wiley   +1 more source

Isolation of pulmonary veins using a thermoreactive implantable device with external energy transfer : evaluation in a porcine model

, 2018
Background: Pulmonary vein isolation (PVI) is a well-established method for the treatment of symptomatic paroxysmal atrial fibrillation, but is only partly successful with a high rate of electrical reconnection.
Boussy, Tim, Clement, Eli, Granada, Juan F, Philpott, Matthew, Reddy, Vivek Y, Schauvliege, Stijn, Stone, Gregg W, Van Langenhove, Glenn, van Loon, Gunther, Vandecasteele, Tim, Vera, Lisse, Willenz, Udi   +11 more
core   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

6 The role of ablation index on repeat pulmonary vein isolation procedures in persistent atrial fibrillation: a short term outcome [PDF]

, 2020
SJ Lennon, James Mannion, Gábor Széplaki, John F. Keaney, Edward T. Keelan, Joseph Galvin, Usama Boles   +6 more
openalex   +1 more source