Results 71 to 80 of about 8,048 (187)

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Extra Corporeal Membrane Oxygenation (ECMO) review of a lifesaving technology [PDF]

, 2015
Extra Corporeal Membrane Oxygenation (ECMO) indications and usage has strikingly progressed over the last 20 years; it has become essential tool in the care of adults and children with severe cardiac and pulmonary dysfunction refractory to conventional ...
Makdisi, George, Wang, I-wen
core   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Gemcitabine-Induced Pulmonary Toxicity: A Case Report of Pulmonary Veno-Occlusive Disease

Clinical Medicine Insights: Oncology, 2015
Introduction Gemcitabine is a chemotherapeutic agent frequently used by for the treatment of several malignancies both in the adjuvant and metastatic setting.
Célia Turco, Marine Jary, Stefano Kim, Mélanie Moltenis, Bruno Degano, Philippe Manzoni, Thierry Nguyen, Bruno Genet, Marie-Blanche Valnet Rabier, Bruno Heyd, Christophe Borg   +10 more
doaj   +2 more sources

Comment on “Awake ECMO for Mid‐Tracheal Obstruction: When a Tracheostomy Isn't Enough”

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT In selected patients with severe central airway obstruction, awake VV‐ECMO may provide a safe bridge to complex airway interventions, preserving spontaneous ventilation and enabling controlled multidisciplinary airway management when conventional strategies are unsafe.
Ilaria Onorati, Emmanuel Martinod
wiley   +1 more source

A retrospective comparison of cyclophosphamide plus antithymocyte globulin with cyclophosphamide plus busulfan as the conditioning regimen for severe aplastic anemia [PDF]

, 2009
Allogeneic hematopoietic stem cell transplantation (AHSCT) is the treatment of choice for young patients with severe aplastic anemia (SAA). The association of antithymocyte globulin (ATG) and cyclophosphamide (CY) is the most frequently used conditioning
Chauffaille, Maria de Lourdes Lopes Ferrari, Oliveira, José Salvador Rodrigues de, Ommati, Larissa Veloso Mendes, Rodrigues, Celso Arrais, Silva, A.r., Silva, L.p.   +5 more
core   +2 more sources

Pre‐operative transcranial Doppler ultrasound assessment of cerebral collateral circulation in children undergoing veno‐arterial extracorporeal membrane oxygenation or cardiac surgery

Journal of Medical Radiation Sciences, Volume 73, Issue S2, Page S109-S116, April 2026.
A pre‐cannulation survey of the circle of Willis (CoW) using transcranial Doppler (TCD) ultrasound was implemented to assess cerebral collateral circulation in children undergoing VA ECMO or cardiac surgery with cervical cannulation. The technique, in use since 2019, employs high‐end ultrasound platforms to assess brain morphology, haemorrhage and ...
Tristan Reddan, Michael Malouf, Prem Venugopal, Jennifer Powell   +3 more
wiley   +1 more source

Digital Data Collection Reduces Terminal Digit Bias in Haemodynamic and Physical Activity Measures in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Accurate measurement of cardiopulmonary hemodynamics and exercise capacity is vital for PAH diagnosis and management. Terminal digit bias in clinical measures introduces non‐differential error. Remote monitoring using implanted devices eliminated this bias, demonstrating its potential to enhance accuracy in both clinical practice and research ...
Alexander M. K. Rothman, Marcelle Paula‐Ribeiro, Eleanor McNally, James Wason, Mark Toshner   +4 more
wiley   +1 more source