Results 61 to 70 of about 8,048 (187)

Pulmonary hypertension phenotypes in patients with systemic sclerosis

European Respiratory Review, 2021
Pulmonary hypertension (PH) commonly affects patients with systemic sclerosis (SSc) and is associated with significant morbidity and increased mortality.
Ashraful Haque, David G. Kiely, Gabor Kovacs, A.A. Roger Thompson, Robin Condliffe   +4 more
doaj   +1 more source

Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. [PDF]

, 2015
Pulmonary arterial hypertension (PAH) is an often fatal disorder resulting from several causes including heterogeneous genetic defects. While mutations in the bone morphogenetic protein receptor type II (BMPR2) gene are the single most common causal ...
Abdalla, Adzhubei, Aldred, Aldred, Archer, Austin, Austin, Austin, Badesch, Best, Best, Chaouat, Chen, Chida, Chida, Chidlow, Choi, Cogan, Cogan, Dahal, David, Deng, Donnelly, Drab, Drake, Elliott, Eyries, Eyries, Feng, Foletta, Frydman, Fujiwara, Germain, Girerd, Girerd, Girerd, Greenwald, Harrison, Harrison, Hinderhofer, Hong, Huang, Humbert, Ishiwata, Jones, Kabata, Koehler, Kumar, Lane, Larkin, Liu, Liu, Long, Ma, Machado, Machado, Machado, Machado, Mache, Mair, Maniatis, McLaughlin, Mercier, Minshall, Murata, Möller, Nasim, Nasim, Nishihara, Nohe, Pfarr, Pfarr, Ranchoux, Remillard, Rigueur, Rosenzweig, Rudarakanchana, Ryan, Shi, Shintani, Simonneau, Smoot, Sobolewski, Soubrier, Sztrymf, Tenorio, Thomson, Trembath, Tuder, Vonk-Noordegraaf, Wang, Wang, Wang, West, West, West, Xu, Young, Yuan, Zhao, Zhao   +100 more
core   +2 more sources

Magnetocardiography combined with machine learning for pulmonary hypertension detection and improved short‐term risk assessment

Interdisciplinary Medicine, EarlyView.
Magnetocardiography (MCG) enables non‐invasive mapping of cardiac magnetic fields. In this study, an MCG‐based machine learning model detects pulmonary hypertension with robust performance. Furthermore, MCG features may improve the accuracy of short‐term risk assessment.
Yuankun Qi, Jiaqi Liang, Kai Ma, Xiaoyu Hu, Yu Zhang, Xiaole Han, Dong Xu, Xu Zhang, Xiaopei Cui, Min Xiang, Hongyu Zhang, Jiancheng Fang   +11 more
wiley   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Pulmonary Hypertension Related to Left-Sided Cardiac Pathology

Pulmonary Medicine, 2011
Pulmonary hypertension (PH) is the end result of a variety of diverse pathologic processes. The chronic elevation in pulmonary artery pressure often leads to right ventricular pressure overload and subsequent right ventricular failure. In patients with
Todd L. Kiefer, Thomas M. Bashore
doaj   +1 more source

Doença pulmonar veno-oclusiva, a propóstio de um caso clínico [PDF]

, 2010
The authors present the case of a 22-year-old female patient, white, referred to the cardiovascular outpatient clinic in November 2006 for pulmonary arterial hypertension.
Carvalho, L, Castro, G, Ferreira, MJ, Marinho da Silva, A, Monteiro, P, Providência, LA, Teixeira, R   +6 more
core  

Defining The Dose Of Gemtuzumab Ozogamicin In Combination With Induction Chemotherapy In Acute Myeloid Leukemia: A Comparison Of 3 Mg/M2 With 6 Mg/M2 In The NCRI AML17 Trial [PDF]

, 2016
Arecent source data meta-analysis of randomized trials in adults assessing the immunoconjugate gemtuzumab ozogamicin combined with standard chemotherapy in acute myeloid leukemia showed a significant survival benefit in patients without an adverse ...
Burnett, Alan, Cavenagh, Jamie, Clark, Richard, Grp, UKNCRIAML Study, Hills, Robert, Jones, Gail, Kell, Jonathan, Khwaja, Asim, Nielsen, Ove Juul, Russell, Nigel, Thomas, Ian   +10 more
core   +3 more sources

Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative
Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter   +15 more
wiley   +1 more source

A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype

Pulmonary Circulation, 2020
Mutations in the gene encoding bone morphogenetic protein receptor type II ( BMPR2 ) have been associated with heritable pulmonary arterial hypertension (HPAH), whereas mutations in the gene encoding eukaryotic translation initiation factor 2 alpha ...
Ifeoma Oriaku, Mallory N. LeSieur, William C. Nichols, Roberto Barrios, C. Gregory Elliott, Adaani Frost   +5 more
doaj   +1 more source

Extracorporeal support for pulmonary resection: current indications and results. [PDF]

, 2016
Extracorporeal assistances are exponentially used for patients, with acute severe but reversible heart or lung failure, to provide more prolonged support to bridge patients to heart and/or lung transplantation.
Gonzalez, M., Gronchi, F., Krueger, T., Perentes, J.Y., Ris, H.B., Rosskopfova, P.   +5 more
core   +2 more sources