Results 71 to 80 of about 2,715,475 (392)

Stringlike Pulse Quantification Study by Pulse Wave in 3D Pulse Mapping [PDF]

The Journal of Alternative and Complementary Medicine, 2012
A stringlike pulse is highly related to hypertension, and many classification approaches have been proposed in which the differentiation pulse wave (dPW) can effectively classify the stringlike pulse indicating hypertension. Unfortunately, the dPW method cannot distinguish the spring stringlike pulse from the stringlike pulse so labeled by physicians ...
Chung-Shing Hu, Cheng-Chang Yeh, Yu-Wen Chu, Xiao-Chen Si, Ching-Hsing Luo, Yu-Feng Chung, Chien-Chen Chang   +6 more
openaire   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Self-referenced characterization of space-time couplings in near single-cycle laser pulses [PDF]

, 2016
We report on the characterization of space-time couplings in high energy sub-2-cycle 770nm laser pulses using a self-referencing single-shot method. Using spatially-encoded arrangement filter-based spectral phase interferometry for direct electric field ...
Austin, D. R., Barilot, T., Greening, D., Marangos, J. P., Matia-Hernando, P., Tisch, J. W. G., Walke, D., Witting, T.   +7 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Techniques for decoding speech phonemes and sounds: A concept [PDF]

, 1975
Techniques studied involve conversion of speech sounds into machine-compatible pulse trains. (1) Voltage-level quantizer produces number of output pulses proportional to amplitude characteristics of vowel-type phoneme waveforms.
Holby, H. G., Lokerson, D. C.
core   +1 more source

Temporal properties of gamma-ray bursts as signatures of jets from the central engine

, 2001
A comprehensive temporal analysis has been performed on the 319 brightest GRBs with T90>2s from the BATSE current catalog. The rise times, fall times, full-widths at half maximum (FWHM), pulse amplitudes and pulse areas were measured and the frequency ...
Arneodo, Atteia, B. McBreen, Band, Belli, Beloborodov, Berger, Bhat, Borgonovo, Brainerd, Castro-Tirado, Chang, Cordes, Costa, Crider, D. Watson, Daigne, Dermer, Eichler, F. Quilligan, Fenimore, Frail, Fryer, Golenetskii, Gögüs, Hanlon, Hurley, Hurley, Hurley, Ioka, K. J. Hurley, Kluzniak, Kobayashi, Kouveliotou, L. Hanlon, Lee, Lee, Li, Liang, Link, MacFadyen, Mallat, Mallat, Mallozzi, Mazets, McBreen, McBreen, Montroll, Mészáros, Mészáros, Mészáros, Nemiroff, Norris, Norris, Paciesas, Paczynski, Paczynski, Panaitescu, Pendleton, Piran, Preece, Quilligan, Ramirez-Ruiz, Ramirez-Ruiz, Rees, Rees, Rhoads, Ruffert, S. McBreen, Salmonson, Sari, Schaefer, Schmidt, Spada, Stern, Stern, Strohmayer, Thompson, Usov, van Paradijs, van Putten, Young   +81 more
core   +1 more source

Is pulsar B0656+14 a very nearby RRAT source? [PDF]

, 2006
The recently discovered RRAT sources are characterized by very bright radio bursts which, while being periodically related, occur infrequently. We find bursts with the same characteristics for the known pulsar B0656+14. These bursts represent pulses from
B. W. Stappers, Becker W., G. A. E. Wright, J. M. Rankin, Lorimer D. R., P. Weltevrede, Popov S. B., Ritchings R. T.   +7 more
core   +2 more sources

Pulse Generator With Constant Pulse Width

, 2014
{"references": ["M. V. Shakursky, V.K. Shakursky, V.V. Ivanov, \"Digital Converter of\nFrequency Deviation Based on Three Frequency Generator,\" East-West\nDesign & Test Symposium, IEEE 2013, pp. 1-4.", "F. Veirano, P. Perez, S. Besio, P. Castro, F.
Lah, Hanif Che, Wee Leong Son, Rozita Borhan   +2 more
openaire   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Circuit counts pulses and indicates time of occurrence of slow pulses [PDF]

, 1969
Counter includes one section which counts the first several pulses, and a second section which counts pulses from a clock between the beginning of a sampling interval and the receipt of the first pulse by the circuit. The number of clock pulses indicates
Baumer, W. E., Timm, J. D.
core   +1 more source